Z-338 facilitates acetylcholine release from enteric neurons due to blockade of muscarinic autoreceptors in guinea pig stomach
M Ogishima, M Kaibara, S Ueki, T Kurimoto… - … of Pharmacology and …, 2000 - ASPET
The mechanism by which Z-338, a novel gastroprokinetic agent, stimulates gastric motility
was studied in relation to muscarinic receptors in the guinea pig. Z-338 (3–30 μM) enhanced …
was studied in relation to muscarinic receptors in the guinea pig. Z-338 (3–30 μM) enhanced …
Involvement of CYP2C9 and UGT2B7 in the metabolism of zaltoprofen, a nonsteroidal anti‐inflammatory drug, and its lack of clinically significant CYP inhibition …
…, A Matthews, M Hall, T Kurimoto - British journal of …, 2002 - Wiley Online Library
Aims To identify the cytochrome P450 (CYP) and UDP‐glucuronosyltransferase (UGT)
isoforms responsible for the formation of the primary metabolite(s) of zaltoprofen, and to predict …
isoforms responsible for the formation of the primary metabolite(s) of zaltoprofen, and to predict …
Synthesis and thromboxane A2 antagonistic activity of indane derivatives
…, H Sato, T Iwakuma, R Sato, T Kurimoto… - Bioorganic & medicinal …, 1999 - Elsevier
A new series of indane derivatives were prepared and evaluated for their thromboxane A2
(TXA2, 1) antagonistic activity. Among these compounds, 24a (Z-335) was found to be a …
(TXA2, 1) antagonistic activity. Among these compounds, 24a (Z-335) was found to be a …
Anti‐Tumor Mechanism of Z‐100, an Immunomodulatory Arabinomannan Extracted from Mycobacterium tuberculosis Strain Aoyama B, on Pulmonary Metastases of …
…, Y Shiraishi, K Yoshinaga, T Kurimoto - Microbiology and …, 2002 - Wiley Online Library
In the present study, the anti‐tumor mechanism of Z‐100 was investigated with the use of
pulmonary metastasis of B16F10 melanoma. In B16F10 mice, Th1 cytokine production (IL‐2, …
pulmonary metastasis of B16F10 melanoma. In B16F10 mice, Th1 cytokine production (IL‐2, …
The anticonvulsant effect of citalopram on El mice, and the levels of tryptophan and tyrosine and their metabolites in the brain
H Kabuto, I Yokoi, M Takei, T Kurimoto, A Mori - Neurochemical research, 1994 - Springer
Serotonin (5-HT) plays an important role in the seizures of El mice since the seizure threshold
of El mice correlates with the 5-HT concentration in the central nervous system. In this …
of El mice correlates with the 5-HT concentration in the central nervous system. In this …
Chronic administration of citalopram inhibited El mouse convulsions and decreased monoamine oxidase-A activity.
…, I Yokoi, A Endo, M Takei, T Kurimoto… - Acta Medica …, 1994 - europepmc.org
Serotonin (5-HT) is thought to play an important role in the seizures of El mice because the
seizure threshold of El mice correlates with the 5-HT concentration in the central nervous …
seizure threshold of El mice correlates with the 5-HT concentration in the central nervous …
Z-335, a new thromboxane A2 receptor antagonist, prevents arterial thrombosis induced by ferric chloride in rats
T Tanaka, R Sato, T Kurimoto - European journal of pharmacology, 2000 - Elsevier
We examined the antithrombotic effect of Z-335 ((±)-sodium [2-(4-chlorophenylsulfonylaminomethyl)indan-5-yl]acetate
monohydrate), an orally active thromboxane A 2 receptor (TP-…
monohydrate), an orally active thromboxane A 2 receptor (TP-…
A new thromboxane receptor antagonist, Z-335, ameliorates experimental thrombosis without prolonging the rat tail bleeding time
…, Y Fukuta, Y Fukuda, M Takei, T Kurimoto… - Thrombosis research, 1998 - Elsevier
We investigated the antithrombotic activity of Z-335, a new thromboxane A 2 receptor antagonist,
using experimental thrombosis models, and also tested its effect on the rat tail bleeding …
using experimental thrombosis models, and also tested its effect on the rat tail bleeding …
Drug–drug interactions of Z-338, a novel gastroprokinetic agent, with terfenadine, comparison with cisapride, and involvement of UGT1A9 and 1A8 in the human …
…, Y Kawabata, K Yonezawa, XC Wu, T Kurimoto - European journal of …, 2004 - Elsevier
In the present study, the inhibitory properties of N-[2-(diisopropylamino)ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxamide
monohydrochloride trihydrate (Z-…
monohydrochloride trihydrate (Z-…
Antiplatelet effect of Z-335, a new orally active and long-lasting thromboxane receptor antagonist
…, Y Nomura, Y Fukuda, S Ito, M Takei, T Kurimoto… - European journal of …, 1998 - Elsevier
We investigated the pharmacological characteristics of Z-335 ((±)-sodium[2-[4-(chlorophenylsulfonylaminomethyl)indan-5-yl]acetate
monohydrate), a new indan derivative. Z-335 …
monohydrate), a new indan derivative. Z-335 …