To clarify the effect of the surface charge of liposomes on percutaneous absorption, the
permeation of liposomal drugs through rat skin was investigated in vitro and in vivo. Liposomes …

In order to quantitatively investigate the importance of transfollicular pathway for drug delivery,
drug penetration through human scalp skin was investigated using liquid formulations …

Nevirapine (NVP) treatment is associated with a significant incidence of skin rash in humans,
and it also causes a similar immune-mediated skin rash in Brown Norway (BN) rats. We …

If we could predict and prevent idiosyncratic drug reactions (IDRs) it would have a profound
effect on drug development and therapy. Given our present lack of mechanistic …

We previously reported that oral formulations containing indomethacin nanoparticles (IND-NPs)
showed high bioavailability, and, consequently, improved therapeutic effects and …

The effect of temperature on the skin permeation of terodiline (TD) hydrochloride and the
free base form was examined. The in vitro penetration experiment at 25–50C was carried out …

Since Ca v 3.2 T-type Ca 2+ channels (T-channels) expressed in the primary afferents and
CNS contribute to intractable pain, we explored T-channel-blocking components in distinct …

The accumulation of amyloid β 1–42 peptide (Aβ 1–42) in retina is implicated in the development
of retinal ganglion cell apoptosis and diabetic retinopathy. In this study we demonstrate …

MATERIALS AND METHODS Materials EPN hydrochloride was a generous gift of Japan
Boehringer Ingelheim Co.(Kawanishi, Japan). Diphenidol, an internal standard for high-…

□ The pharmacokinetics of aniracetam (AP), a new cognitive performance enhancer, and its
main metabolites was investigated after intravenous (iv) and oral administrations to rat. The …