A multiple dose study of prasugrel (CS‐747), a novel thienopyridine P2Y12 inhibitor, compared with clopidogrel in healthy humans

…, H Naganuma, JT Brandt, T Hirota… - British journal of …, 2007 - Wiley Online Library
Aims This double‐blind, placebo‐controlled trial was designed to evaluate the pharmacodynamics,
pharmacokinetics, safety, and tolerability of prasugrel (CS‐747, LY640315), a novel …

Inhibition ofE. coli growth by fullerene derivatives and inhibition mechanism

T Mashino, K Okuda, T Hirota, M Hirobe… - Bioorganic & medicinal …, 1999 - Elsevier
Cationic ammonium fullerene derivatives (C 60 -bis(N,N-dimethylpyrrolidinium iodide) and
C 60 -bis(N-methylpiperazinium iodide)) suppressed E. coli growth, whereas an anionic …

Activity of capuramycin analogues against Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium intracellularein vitro and in vivo

…, N Yamamura, M Hoshi, T Hirota - Journal of …, 2004 - academic.oup.com
Objectives: The antimycobacterial activities of RS-112997, RS-124922 and RS-118641, three
capuramycin analogues that inhibit phospho-N-acetylmuramyl-pentapeptide translocase, …

Respiratory chain inhibition by fullerene derivatives: hydrogen peroxide production caused by fullerene derivatives and a respiratory chain system

T Mashino, N Usui, K Okuda, T Hirota… - Bioorganic & medicinal …, 2003 - Elsevier
Fullerene is a new type of carbon allotrope. We have shown that the fullerene derivative C
60 -bis(N,N-dimethylpyrrolidinium iodide), a regio isomer mixture, inhibited Escherichia coli …

Platelet inhibitory activity and pharmacokinetics of prasugrel (CS-747) a novel thienopyridine P2Y12 inhibitor: A single ascending dose study in healthy humans

…, H Naganuma, JT Brandt, N Matsushima, T Hirota… - Platelets, 2006 - Taylor & Francis
We assessed the tolerability, pharmacodynamics as measured by inhibition of platelet
aggregation (IPA), and pharmacokinetics of prasugrel (CS-747, LY640315), a novel …

Action mechanism of amphipathic peptides gramicidin S and melittin on erythrocyte membrane

…, C Ninomiya, M Kuroko, H Kobayashi, T Hirota… - … et Biophysica Acta (BBA …, 1988 - Elsevier
Amphipathic peptides gramicidin S and melittin caused a characteristic colloid-osmotic
hemolysis on human erythrocytes; that is, the peptides produced initially a small membrane …

[HTML][HTML] Enantioselective pharmacokinetics of α-lipoic acid in rats

…, H Okamoto, N Ikuta, K Terao, T Hirota - International journal of …, 2015 - mdpi.com
… Ryota Uchida and Takashi Hirota contributed to … Takashi Hirota contributed to the drafting
of the manuscript; Ryota Uchida, Hinako Okamoto, Naoko Ikuta, Keiji Terao and Takashi Hirota

Characterization of CS-023 (RO4908463), a novel parenteral carbapenem antibiotic, and meropenem as substrates of human renal transporters

…, D Sugiyama, E Kamiyama, T Tokui, T Hirota… - Drug metabolism and …, 2007 - Elsevier
To characterize the renal handling of CS-023 (RO4908463), a novel parenteral carbapenem
antibiotic, and meropenem in humans, we examined their affinities as substrates to human …

Syntheses of 3-substituted 1-methyl-6-phenylpyrimido [5, 4-e]-1, 2, 4-triazine-5, 7 (1H, 6H)-diones (6-phenyl analogs of toxoflavin) and their 4-oxides, and evaluation …

T Nagamatsu, H YAMASAKI, T HIROTA… - Chemical and …, 1993 - jstage.jst.go.jp
6-Phenyl analogs of toxoflavin {1-methyl-6-phenylpyrimido [5, 4-e]-1, 2, 4-triazine-5, 7 (1H,
6H)-diones}(7a-f) and their 4-oxides (8a-f) were synthesized by nitrosative or nitrative …

Synthesis of Various Water-Soluble G60 Derivatives and Their Superoxide-Quenching Activity

K Okuda, T Hirota, M Hirobe, T Nagano… - Fullerene science …, 2000 - Taylor & Francis
In order to examine the utility of fullerene as a medicinal application, we evaluated the reaction
between fullerene derivatives and active oxygen species in vitro. This paper describes …