Comparative study of the dose-dependence of OATP1B inhibition by rifampicin using probe drugs and endogenous substrates in healthy volunteers

I Takehara, T Yoshikado, K Ishigame, D Mori… - Pharmaceutical …, 2018 - Springer
Purpose To evaluate association of the dose-dependent effect of rifampicin, an OATP1B
inhibitor, on the plasma concentration–time profiles among OATP1B substrates drugs and …

Investigation of glycochenodeoxycholate sulfate and chenodeoxycholate glucuronide as surrogate endogenous probes for drug interaction studies of OATP1B1 and …

…, H Terashima, T Nakayama, T Yoshikado… - Pharmaceutical …, 2017 - Springer
Purpose To assess the use of glycochenodeoxycholate-3-sulfate (GCDCA-S) and
chenodeoxycholate 3- or 24-glucuronide (CDCA-3G or -24G) as surrogate endogenous substrates in …

PBPK modeling of coproporphyrin I as an endogenous biomarker for drug interactions involving inhibition of hepatic OATP1B1 and OATP1B3

T Yoshikado, K Toshimoto, K Maeda… - CPT …, 2018 - Wiley Online Library
The aim of the present study was to establish a physiologically based pharmacokinetic (PBPK)
model for coproporphyrin I (CP‐I), a biomarker supporting the prediction of drug‐drug …

Effect of OATP1B1 genotypes on plasma concentrations of endogenous OATP1B1 substrates and drugs, and their association in healthy volunteers

D Mori, Y Kashihara, T Yoshikado, M Kimura… - Drug metabolism and …, 2019 - Elsevier
This study aimed to elucidate the impact of OATP1B1 genotype (*1b/*1b, *1b/*15, and *15/*15)
on plasma concentrations of endogenous OATP1B1 substrates. Healthy volunteers with …

Itraconazole-induced cholestasis: involvement of the inhibition of bile canalicular phospholipid translocator MDR3/ABCB4

T Yoshikado, T Takada, T Yamamoto, H Yamaji… - Molecular …, 2011 - ASPET
Biliary secretion of bile acids and phospholipids, both of which are essential components of
biliary micelles, are mediated by the bile salt export pump (BSEP/ABCB11) and multidrug …

Small-dosing clinical study: pharmacokinetic, pharmacogenomic (SLCO2B1 and ABCG2), and interaction (atorvastatin and grapefruit juice) profiles of 5 probes for …

Y Kashihara, I Ieiri, T Yoshikado, K Maeda… - Journal of …, 2017 - Elsevier
The aims of this study were (1) to investigate the effects of atorvastatin (10 mg, therapeutic
dose) and grapefruit juice (GFJ), inhibitors of OATP2B1, on the pharmacokinetics of substrates …

Comparison of methods for estimating unbound intracellular-to-medium concentration ratios in rat and human hepatocytes using statins

T Yoshikado, K Toshimoto, T Nakada, K Ikejiri… - Drug Metabolism and …, 2017 - ASPET
It is essential to estimate concentrations of unbound drugs inside the hepatocytes to predict
hepatic clearance, efficacy, and toxicity of the drugs. The present study was undertaken to …

NPC2 regulates biliary cholesterol secretion via stimulation of ABCG5/G8-mediated cholesterol transport

Y Yamanashi, T Takada, T Yoshikado, JI Shoda… - Gastroenterology, 2011 - Elsevier
Background & Aims Biliary cholesterol secretion helps maintain cholesterol homeostasis; it
is regulated by the cholesterol exporter adenosine triphosphate–binding cassettes G5 and …

Physiologically‐based pharmacokinetic model‐based translation of OATP1B‐mediated drug–drug interactions from coproporphyrin I to probe drugs

T Mochizuki, Y Aoki, T Yoshikado… - Clinical and …, 2022 - Wiley Online Library
The accurate prediction of OATP1B‐mediated drug–drug interactions (DDIs) is challenging
for drug development. Here, we report a physiologically‐based pharmacokinetic (PBPK) …

Clarification of the mechanism of clopidogrel-mediated drug–drug interaction in a clinical cassette small-dose study and its prediction based on in vitro information

SJ Kim, T Yoshikado, I Ieiri, K Maeda, M Kimura… - Drug Metabolism and …, 2016 - ASPET
Clopidogrel is reported to be associated with cerivastatin-induced rhabdomyolysis, and
clopidogrel and its metabolites are capable of inhibiting CYP2C8 and OATP 1B1 in vitro. The …