Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5′-flanking region

K Yoshinari, N Yoda, T Toriyabe, Y Yamazoe - Biochemical pharmacology, 2010 - Elsevier
Phenobarbital has long been known to increase cellular levels of CYP1A1 and CYP1A2
possibly through a pathway(s) independent of aryl hydrocarbon receptor. We have investigated …

Involvement of Vitamin D receptor in the intestinal induction of human ABCB1

S Tachibana, K Yoshinari, T Chikada, T Toriyabe… - Drug metabolism and …, 2009 - ASPET
ABCB1 (P-glycoprotein) is an efflux transporter that limits the cellular uptake levels of various
drugs in intestine, brain, and other tissues. The expression of human ABCB1 has recently …

Unveiling a new essential cis element for the transactivation of the CYP3A4 gene by xenobiotics

T Toriyabe, K Nagata, T Takada, Y Aratsu… - Molecular …, 2009 - ASPET
Pregnane X receptor (PXR) has been shown to form a heterodimer with retinoid X receptor
α (RXRα) and to bind to the distal nuclear receptor-binding element 1 and an everted repeat …

Assessment of human pregnane X receptor involvement in pesticide-mediated activation of CYP3A4 gene

T Matsubara, W Noracharttiyapot, T Toriyabe… - Drug metabolism and …, 2007 - ASPET
Assessment of foreign chemical inducibility on CYP3A4 is necessary to optimize drug
therapies. The properties of chemicals such as pesticides, however, are not well investigated. In …

Activation of p38 Mitogen-Activated Protein Kinase by Clotrimazole Induces Multidrug Resistance–Associated Protein 3 Activation through a Novel Transcriptional …

…, T Kumagai, S Kanno, S Matsui, T Toriyabe… - … of Pharmacology and …, 2016 - ASPET
Multidrug resistance–associated protein 3 (MRP3) is a basolaterally localized transporter in
the liver and contributes to the transport of various metabolites such as conjugates of …

Activation of p38 MAPK by clotrimazole led to MRP3 activation through a novel transcriptional element

…, T Kumagai, S Kanno, S Matsui, T Toriyabe… - … of Pharmacology and …, 2016 - ASPET
Multidrug resistance-associated protein 3 (MRP3) is a basolaterally localized transporter in
the liver and contributes to the transport of various metabolites such as conjugates of …

7-1 Overview “Challenge of Clinical Risk Minimization through Enhanced Nonclinical and Clinical Joint Discussion− Practical Approach−”

ES Geary - Bulletin of Safety Evaluation Forum, 2013 - jstage.jst.go.jp
… And Dr Takayoshi Toriyabe from the PMDA described the agency's current and planned
work program for utilization of biomarkers and pharmacogenomics in pharmacovigilance. …

Constitutive androstane receptor transactivates the hepatic expression of mouse Dhcr24 and human DHCR24 encoding a cholesterogenic enzyme 24 …

K Yoshinari, H Ohno, S Benoki, Y Yamazoe - Toxicology letters, 2012 - Elsevier
Takayoshi Toriyabe and Mr. Noriaki Yoda for their technical assistance in the experiments
with human hepatocytes. This study was supported in part by Grant-in-Aid from Ministry of …

[CITATION][C] DRUG METABOLISM AND DISPOSITION

SK Quinney, JC Gorski, DR Jones, SD Hall, T Toriyabe… - ASPET

[CITATION][C] A NOVEL CIS-ELEMENT ESSENTIAL FOR THE TRANSACTIVATION OF THE CYP3A4 GENE IN RESPONSE TO RIFAMPICIN

T Toriyabe, T Takada, Y Aratsu… - DRUG …, 2007 - … & FRANCIS INC 325 CHESTNUT ST …