User profiles for Taosheng Chen
Taosheng ChenFull Member, St. Jude Children's Research Hospital Verified email at stjude.org Cited by 8153 |
[HTML][HTML] Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor γ (PPARγ) agonists: PPARγ co-association with transcription …
XY Yang, LH Wang, T Chen, DR Hodge… - Journal of biological …, 2000 - ASBMB
T lymphocyte activation is highlighted by the induction of interleukin-2 (IL-2) gene expression,
which governs much of the early lymphocyte proliferation responses. Peroxisome …
which governs much of the early lymphocyte proliferation responses. Peroxisome …
Interleukin 6 activates androgen receptor-mediated gene expression through a signal transducer and activator of transcription 3-dependent pathway in LNCaP …
T Chen, LH Wang, WL Farrar - Cancer research, 2000 - AACR
Interleukin 6 (IL-6) is a cytokine that regulates not only immune and inflammatory responses
but also the growth of some tumors, including prostate carcinomas. IL-6 signals through …
but also the growth of some tumors, including prostate carcinomas. IL-6 signals through …
Role of CAR and PXR in xenobiotic sensing and metabolism
Introduction: The xenobiotic detoxification system, which protects the human body from external
chemicals, comprises drug-metabolizing enzymes and transporters whose expressions …
chemicals, comprises drug-metabolizing enzymes and transporters whose expressions …
[PDF][PDF] BOK is a non-canonical BCL-2 family effector of apoptosis regulated by ER-associated degradation
The mitochondrial pathway of apoptosis is initiated by mitochondrial outer membrane
permeabilization (MOMP). The BCL-2 family effectors BAX and BAK are thought to be absolutely …
permeabilization (MOMP). The BCL-2 family effectors BAX and BAK are thought to be absolutely …
[PDF][PDF] Efficacy of retinoids in IKZF1-mutated BCR-ABL1 acute lymphoblastic leukemia
…, D Payne-Turner, MJ Althoff, G Song, SC Chen… - Cancer cell, 2015 - cell.com
Alterations of IKZF1, encoding the lymphoid transcription factor IKAROS, are a hallmark of
high-risk acute lymphoblastic leukemia (ALL), however the role of IKZF1 alterations in ALL …
high-risk acute lymphoblastic leukemia (ALL), however the role of IKZF1 alterations in ALL …
[HTML][HTML] A2B adenosine and P2Y2 receptors stimulate mitogen-activated protein kinase in human embryonic kidney-293 cells: cross-talk between cyclic AMP and …
… Taosheng Chen Taosheng Chen …
Mitophagy restricts BAX/BAK-independent, Parkin-mediated apoptosis
Degradation of defective mitochondria is an essential process to maintain cellular homeostasis
and it is strictly regulated by the ubiquitin-proteasome system (UPS) and lysosomal …
and it is strictly regulated by the ubiquitin-proteasome system (UPS) and lysosomal …
Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions
M Sinz, S Kim, Z Zhu, T Chen, M Anthony… - Current drug …, 2006 - ingentaconnect.com
The human transcription factor pregnane X receptor (hPXR) is a key regulator of enzyme
expression, especially cytochrome P450 3A4 (CYP3A4). Due to the prominence of CYP3A4 in …
expression, especially cytochrome P450 3A4 (CYP3A4). Due to the prominence of CYP3A4 in …
PXR: more than just a master xenobiotic receptor
PO Oladimeji, T Chen - Molecular pharmacology, 2018 - ASPET
Pregnane X receptor (PXR) is a nuclear receptor considered to be a master xenobiotic
receptor that coordinately regulates the expression of genes encoding drug-metabolizing …
receptor that coordinately regulates the expression of genes encoding drug-metabolizing …
Oncogenic role and therapeutic targeting of ABL-class and JAK-STAT activating kinase alterations in Ph-like ALL
New therapies for Philadelphia chromosome–like acute lymphoblastic leukemia (Ph-like ALL)
patients are urgently needed. The genetic landscape of Ph-like ALL is characterized by a …
patients are urgently needed. The genetic landscape of Ph-like ALL is characterized by a …