Breast cancer resistance protein (ABCG2) in clinical pharmacokinetics and drug interactions: practical recommendations for clinical victim and perpetrator drug-drug …
Breast cancer resistance protein (BCRP; ABCG2) limits intestinal absorption of low-permeability
substrate drugs and mediates biliary excretion of drugs and metabolites. Based on …
substrate drugs and mediates biliary excretion of drugs and metabolites. Based on …
[HTML][HTML] Conformational analysis of human ATP-binding cassette transporter ABCB1 in lipid nanodiscs and inhibition by the antibodies MRK16 and UIC2
TK Ritchie, H Kwon, WM Atkins - Journal of Biological Chemistry, 2011 - ASBMB
The human ATP-binding cassette (ABC) transporter, P-glycoprotein (P-gp; ABCB1), mediates
the ATP-dependent efflux of a variety of drugs. As a result, P-gp plays a critical role in …
the ATP-dependent efflux of a variety of drugs. As a result, P-gp plays a critical role in …
Organic anion transporting polypeptide 2B1–more than a glass-full of drug interactions
SJ McFeely, L Wu, TK Ritchie, J Unadkat - Pharmacology & therapeutics, 2019 - Elsevier
The importance of uptake transporters in determining drug disposition is increasingly
appreciated. While the focus of regulatory agencies worldwide has been on the hepatic organic …
appreciated. While the focus of regulatory agencies worldwide has been on the hepatic organic …
Drug disposition and drug-drug interaction data in 2013 FDA new drug applications: a systematic review
J Yu, TK Ritchie, A Mulgaonkar… - Drug Metabolism and …, 2014 - ASPET
The aim of the present work was to perform a systematic review of drug metabolism, transport,
pharmacokinetics, and DDI data available in the NDAs approved by the FDA in 2013, …
pharmacokinetics, and DDI data available in the NDAs approved by the FDA in 2013, …
What can be learned from recent new drug applications? A systematic review of drug interaction data for drugs approved by the US FDA in 2015
J Yu, Z Zhou, KH Owens, TK Ritchie… - Drug Metabolism and …, 2017 - ASPET
As a follow up to previous reviews, the aim of the present analysis was to systematically
examine all drug metabolism, transport, pharmacokinetics (PK), and drug-drug interaction (DDI) …
examine all drug metabolism, transport, pharmacokinetics (PK), and drug-drug interaction (DDI) …
Key findings from preclinical and clinical drug interaction studies presented in new drug and biological license applications approved by the Food and Drug …
J Yu, TK Ritchie, Z Zhou… - Drug Metabolism and …, 2016 - ASPET
Regulatory approval documents contain valuable information, often not published, to assess
the drug–drug interaction (DDI) profile of newly marketed drugs. This analysis aimed to …
the drug–drug interaction (DDI) profile of newly marketed drugs. This analysis aimed to …
The multidrug resistance pump ABCB1 is a substrate for the ubiquitin ligase NEDD4-1
BG Akkaya, JK Zolnerciks, TK Ritchie… - Molecular membrane …, 2015 - Taylor & Francis
The ATP Binding Cassette transporter ABCB1 can export the neurotoxic peptide β-amyloid
from endothelial cells that line the blood-brain barrier (BBB). This has the potential to lower …
from endothelial cells that line the blood-brain barrier (BBB). This has the potential to lower …
Identification and evaluation of clinical substrates of organic anion transporting polypeptides 1B1 and 1B3
SJ McFeely, TK Ritchie, J Yu… - Clinical and …, 2019 - Wiley Online Library
Organic anion transporting polypeptides (OATPs) 1B1 and 1B3 facilitate the uptake of drugs
and endogenous compounds into the liver. In recent years, the impact of these transporters …
and endogenous compounds into the liver. In recent years, the impact of these transporters …
Inhibitors of Organic Anion‐Transporting Polypeptides 1B1 and 1B3: Clinical Relevance and Regulatory Perspective
SJ McFeely, TK Ritchie, J Yu… - The Journal of …, 2020 - Wiley Online Library
Organic anion‐transporting polypeptides (OATPs) 1B1 and 1B3 are the primary hepatic
transporters responsible for uptake of drugs into the liver and, as such, an area of growing …
transporters responsible for uptake of drugs into the liver and, as such, an area of growing …
Variability in In Vitro OATP1B1/1B3 Inhibition Data: Impact of Incubation Conditions on Variability and Subsequent Drug Interaction Predictions
SJ McFeely, TK Ritchie… - Clinical and …, 2020 - Wiley Online Library
As the research into the organic anion transporting polypeptides ( OATP s) continues to grow,
it is important to ensure that the data generated are accurate and reproducible. In the in …
it is important to ensure that the data generated are accurate and reproducible. In the in …