Hemoglobin–ligand binding: Understanding Hb function and allostery on atomic level
The major physiological function of hemoglobin (Hb) is to bind oxygen in the lungs and
deliver it to the tissues. This function is regulated and/or made efficient by endogenous …
deliver it to the tissues. This function is regulated and/or made efficient by endogenous …
Glucuronidation of active tamoxifen metabolites by the human UDP glucuronosyltransferases
…, RM Balliet, G Chen, T Boyiri… - Drug metabolism and …, 2007 - ASPET
Tamoxifen (TAM) is an antiestrogen that has been widely used in the treatment and prevention
of breast cancer in women. One of the major mechanisms of metabolism and elimination …
of breast cancer in women. One of the major mechanisms of metabolism and elimination …
Identification of tobacco-derived compounds in human pancreatic juice
…, N Trushin, S Akerkar, T Boyiri… - Chemical research in …, 2002 - ACS Publications
Cancer of the pancreas is the fourth leading cause of cancer mortality in the USA with an
estimated 28 900 deaths in 2001. Several factors have been implicated in the etiology of this …
estimated 28 900 deaths in 2001. Several factors have been implicated in the etiology of this …
Influence of selenium-enriched yeast supplementation on biomarkers of oxidative damage and hormone status in healthy adult males: a clinical pilot study
K El-Bayoumy, JP Richie Jr, T Boyiri, D Komninou… - … Biomarkers & Prevention, 2002 - AACR
The mechanisms responsible for the protective role of selenium against thedevelopment of
prostate cancer remain to be determined (LC Clark et al., J. Am. Med. Assoc., 276: 1957–…
prostate cancer remain to be determined (LC Clark et al., J. Am. Med. Assoc., 276: 1957–…
How allosteric effectors can bind to the same protein residue and produce opposite shifts in the allosteric equilibrium
DJ Abraham, MK Safo, T Boyiri… - Biochemistry, 1995 - ACS Publications
Revised Manuscript Received June 27, 1995® abstract: Monoaldehyde allosteric effectors
of hemoglobin were designed, using molecular modeling software (GRID), to form a Schiff …
of hemoglobin were designed, using molecular modeling software (GRID), to form a Schiff …
Bisaldehyde allosteric effectors as molecular ratchets and probes
T Boyiri, MK Safo, RE Danso-Danquah, J Kister… - Biochemistry, 1995 - ACS Publications
MATERIALS AND METHODS Materials and General Procedure. All reagents and starting
materials for the synthesis were purchased from Aldrich Chemical Co., Lancaster, Kodak, and …
materials for the synthesis were purchased from Aldrich Chemical Co., Lancaster, Kodak, and …
Identification of 5-(Deoxyguanosin-N2-yl)- 1,2-dihydroxy-1,2-dihydro-6-aminochrysene as the Major DNA Lesion in the Mammary Gland of Rats Treated with the …
…, JM Lin, J Krzeminski, T Boyiri… - Chemical research in …, 2004 - ACS Publications
The environmental pollutant 6-nitrochrysene (6-NC) is a potent carcinogen in several animal
models including the rat mammary gland. 6-NC can be activated to intermediates that can …
models including the rat mammary gland. 6-NC can be activated to intermediates that can …
Comparative tumorigenicity of the environmental pollutant 6-nitrochrysene and its metabolites in the rat mammary gland
K El-Bayoumy, D Desai, T Boyiri, J Rosa… - Chemical research in …, 2002 - ACS Publications
Human exposure to the class of nitropolynuclear aromatic hydrocarbons is via inhalation and/or
ingestion. Therefore, one of the goals of this study was to determine the propensity of the …
ingestion. Therefore, one of the goals of this study was to determine the propensity of the …
Mammary carcinogenesis and molecular analysis of in vivo cII gene mutations in the mammary tissue of female transgenic rats treated with the …
T Boyiri, J Guttenplan, M Khmelnitsky… - …, 2004 - academic.oup.com
We determined the mutant fractions (MF) and mutational specificities in the cII gene in
histologically confirmed normal, non-involved and tumor mammary tissues of female transgenic (…
histologically confirmed normal, non-involved and tumor mammary tissues of female transgenic (…
Human cytochromes P450 1A1 and 1B1 catalyze ring oxidation but not nitroreduction of environmental pollutant mononitropyrene isomers in primary cultures of …
…, FP Guengerich, AK Sharma, T Boyiri… - Chemical research in …, 2004 - ACS Publications
The position of the nitro group determines the relative carcinogenic activities of mono-nitropyrene
isomers (mono-NPs) in the rat mammary gland. To determine whether the results …
isomers (mono-NPs) in the rat mammary gland. To determine whether the results …