User profiles for Terrence J. Monks
Terrence J MonksProfessor and Chair, Pharmacology & Toxicology, University of Arizona Verified email at pharmacy.arizona.edu Cited by 11974 |
Role of quinones in toxicology
Quinones represent a class of toxicological intermediates which can create a variety of
hazardous effects in vivo, including acute cytotoxicity, immunotoxicity, and carcinogenesis. The …
hazardous effects in vivo, including acute cytotoxicity, immunotoxicity, and carcinogenesis. The …
Quinone chemistry and toxicity
TJ Monks, RP Hanzlik, GM Cohen, D Ross… - Toxicology and applied …, 1992 - Elsevier
Quinones are ubiquitous in nature and constitute an important class of naturally occurring
compounds that are found in plants, fungi, and bacteria and that function primarily as …
compounds that are found in plants, fungi, and bacteria and that function primarily as …
The metabolism and toxicity of quinones, quinonimines, quinone methides, and quinone-thioethers
TJ Monks, DC Jones - Current drug metabolism, 2002 - ingentaconnect.com
Quinones are ubiquitous in nature and constitute an important class of naturally occurring
compounds found in plants, fungi and bacteria. Human exposure to quinones therefore occurs …
compounds found in plants, fungi and bacteria. Human exposure to quinones therefore occurs …
Glutathione conjugate mediated toxicities
TJ Monks, MW Anders, W Dekant, JL Stevens… - Toxicology and applied …, 1990 - Elsevier
Glutathione (γ-glutamyl-l-cysteinylglycine; GSH) is present in high concentrations in most
living cells and participates in a variety of vital cellular reactions. In particular, GSH protects …
living cells and participates in a variety of vital cellular reactions. In particular, GSH protects …
The Cytoprotective Effect of N-acetyl-L-cysteine against ROS-Induced Cytotoxicity Is Independent of Its Ability to Enhance Glutathione Synthesis
F Zhang, SS Lau, TJ Monks - Toxicological Sciences, 2011 - academic.oup.com
2,3,5-Tris(glutathion-S-yl)-hydroquinone (TGHQ), a metabolite of hydroquinone, is toxic to
renal proximal tubule epithelial cells. TGHQ retains the ability to redox cycle and create an …
renal proximal tubule epithelial cells. TGHQ retains the ability to redox cycle and create an …
Sequential oxidation and glutathione addition to 1, 4-benzoquinone: correlation of toxicity with increased glutathione substitution.
SS Lau, BA Hill, RJ Highet, TJ Monks - Molecular pharmacology, 1988 - ASPET
The chemical reaction of 1,4-benzoquinone with glutathione results in the formation of adducts
that exhibit increasing degrees of glutathione substitution. Purification of these adducts …
that exhibit increasing degrees of glutathione substitution. Purification of these adducts …
Metformin scavenges methylglyoxal to form a novel imidazolinone metabolite in humans
Methylglyoxal (MG) is a highly reactive dicarbonyl compound involved in the formation of
advanced glycation endproducts (AGE). Levels of MG are elevated in patients with type-2 …
advanced glycation endproducts (AGE). Levels of MG are elevated in patients with type-2 …
Acetaminophen-induced hepatotoxicity
JA Hinson, LR Pohl, TJ Monks, JR Gillette - Life sciences, 1981 - Elsevier
In large doses the commonly used analgesic acetaminophen produces a centrilobular
hepatic necrosis in man and experimental animals. The toxicity is mediated by a reactive …
hepatic necrosis in man and experimental animals. The toxicity is mediated by a reactive …
Toxicology of quinone-thioethers
TJ Monks, SS Lau - Critical reviews in toxicology, 1992 - Taylor & Francis
Cytotoxicity associated with exposure to quinones has generally been attributed to either
redox cycling, and the subsequent development of “oxidative stress” and/or to their interaction …
redox cycling, and the subsequent development of “oxidative stress” and/or to their interaction …
In situ, dual-mode monitoring of organ-on-a-chip with smartphone-based fluorescence microscope
S Cho, A Islas-Robles, AM Nicolini, TJ Monks… - Biosensors and …, 2016 - Elsevier
The use of organ-on-a-chip (OOC) platforms enables improved simulation of the human
kidney's response to nephrotoxic drugs. The standard method of analyzing nephrotoxicity from …
kidney's response to nephrotoxic drugs. The standard method of analyzing nephrotoxicity from …