… Author links open overlay panel Tsuneo Deguchi , Hiroyuki Kusuhara , Akira Takadate ,
Hitoshi Endou , Masaki Otagiri, Yuichi Sugiyama … Deguchi, M. Takano, et al. …

Renal impairment is associated with CNS dysfunctions and the accumulation of uremic
toxins, such as indoxyl sulfate, in blood. To evaluate the relevance of indoxyl sulfate to CNS …

Systemic lupus erythematosus (SLE) is characterized by the expansion of extrafollicular
pathogenic B cells derived from newly activated naive cells. Although these cells express …

The mechanism that removes homovanillic acid (HVA), an end metabolite of dopamine, from
the brain is still poorly understood. The purpose of this study is to identify and characterize …

… Author links open overlay panel Tsuneo Deguchi , Sumio Ohtsuki , Masaki Otagiri, Hitomi
Takanaga , Hiroshi Asaba , Shinobu Mori , Prof Tetsuya Terasaki Ph.D. …

Hippurate (HA) is a harmful uremic toxin that accumulates during chronic renal failure, and
failure of the excretion system for uremic toxins is thought to be responsible. Recently, we …

Renal failure causes multiple physiological changes involving CNS dysfunction. In cases of
uremia, there is close correlation between plasma levels of uremic toxins [eg 3‐carboxy‐4‐…

The aim of the current study was to evaluate the accuracy of allometric scaling methods for
drugs metabolized by UDP-glucuronosyltransferases (UGTs), such as ketoprofen, imipramine…

The aim of this study was to understand the mechanisms that underlie the renal elimination
of albumin-bound uremic toxins, particularly the highly bound furan acid 3-carboxy-4-methyl-…

Although “genomically” humanized animals are invaluable tools for generating human disease
models as well as for biomedical research, their development has been mainly restricted …