Sniffing neuropeptides: a transnasal approach to the human brain

J Born, T Lange, W Kern, GP McGregor, U Bickel… - Nature …, 2002 - nature.com
Neuropeptides act as neuronal messengers in the brain, influencing many neurobehavioral
functions 1. Their experimental and therapeutic use in humans has been hampered because…

Delivery of peptides and proteins through the blood–brain barrier

U Bickel, T Yoshikawa, WM Pardridge - Advanced drug delivery reviews, 2001 - Elsevier
Peptide and protein therapeutics are generally excluded from transport from blood to brain,
owing to the negligible permeability of these drugs to the brain capillary endothelial wall, …

How to measure drug transport across the blood-brain barrier

U Bickel - NeuroRx, 2005 - Springer
The extent to which a substance in the circulation gains access to the CNS needs to be
determined for potential neuropharmaceuticals as well as for drug candidates with primary …

Pharmacologic effects in vivo in brain by vector-mediated peptide drug delivery.

U Bickel, T Yoshikawa, EM Landaw… - Proceedings of the …, 1993 - National Acad Sciences
Pharmacologic effects in brain caused by systemic administration of neuropeptides are
prevented by poor transport of the peptide through the brain vascular endothelium, which …

Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo …

…, A von Harpe, D Fischer, H Petersen, U Bickel… - Journal of Controlled …, 2003 - Elsevier
Low-molecular-weight polyethylenimine (LMW-PEI) was synthesized by the acid-catalyzed,
ring-opening polymerization of aziridine and compared with commercially available high-…

Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood-brain barrier in mouse

HJ Lee, B Engelhardt, J Lesley, U Bickel… - … of Pharmacology and …, 2000 - ASPET
Drug targeting through the brain capillary endothelium, which forms the blood-brain barrier (BBB)
in vivo, may be achieved with peptidomimetic monoclonal antibodies that target …

Acute endocrine failure after brain death?

HJ Gramm, H Meinhold, U Bickel, J Zimmermann… - …, 1992 - journals.lww.com
After brain death, 32 potential organ donors were studied to determine serum and plasma
concentrations of hypothalamic-pituitary hormones, thyroid hormones, and cortisol over a …

The structure of PEG-modified poly (ethylene imines) influences biodistribution and pharmacokinetics of their complexes with NF-κB decoy in mice

…, D Fischer, K Voigt, T Kissel, U Bickel - Pharmaceutical …, 2002 - Springer
Purpose. To study the relationship between structure of poly(ethylene imine-co-ethylene
glycol), PEI-PEG, copolymers and physicochemical properties as well as in vivo behavior of …

Effect of poly (ethylene imine) molecular weight and pegylation on organ distribution and pharmacokinetics of polyplexes with oligodeoxynucleotides in mice

…, B Osburg, H Petersen, T Kissel, U Bickel - Drug Metabolism and …, 2004 - ASPET
The in vivo body distribution and the pharmacokinetics of a 20mer double-stranded nuclear
factor κB decoy oligodeoxynucleotide (ODN) complexed with 25-kDa poly(ethylene imine) (…

Brain microvascular and astrocyte localization of P‐glycoprotein

…, PL Golden, YS Kang, U Bickel - Journal of …, 1997 - Wiley Online Library
The hypothesis that P‐glycoprotein plays a functional role at the brain capillary endothelium,
which makes up the blood‐brain barrier in vivo, is based largely on immunocytochemical …