3, 4‐Methylenedioxymethamphetamine (MDMA,“Ecstasy”): pharmacology and toxicology in animals and humans

TD STEELE, UNAD McCANN, GA RICAURTE - Addiction, 1994 - Wiley Online Library
(±)3,4‐Methylenedioxymethamphetamine (MDMA, “Ecstasy”), a ring‐substituted amphetamine
derivative first synthesized in 1914, has emerged as a popular recreational drug of abuse …

Neurotoxic amphetamine analogues: effects in monkeys and implications for humans.

GA Ricaurte, UNAD McCANN - Annals of the New York Academy of …, 1992 - europepmc.org
A wealth of evidence has accrued over the last 20 years indicating that certain amphetamine
analogues have the potential to damage central monoaminergic neurons. For example, …

(±) 3, 4-Methylenedioxymethamphetamine ('Ecstasy')-induced serotonin neurotoxicity: studies in animals

GA Ricaurte, J Yuan, UD McCann - Neuropsychobiology, 2000 - karger.com
The popular recreational drug, (±)3,4-methylenedioxymethamphetamine (MDMA; ‘Ecstasy’)
is a potent and selective brain serotonin (5-HT) neurotoxin in animals. MDMA-induced 5-HT …

Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later

…, MW Johnson, UD McCann… - Journal of …, 2008 - journals.sagepub.com
Psilocybin has been used for centuries for religious purposes; however, little is known
scientifically about its long-term effects. We previously reported the effects of a double-blind study …

Positron emission tomographic evidence of toxic effect of MDMA (“Ecstasy”) on brain serotonin neurons in human beings

UD McCann, Z Szabo, U Scheffel, RF Dannals… - The Lancet, 1998 - thelancet.com
Background (±)3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") is a popular
recreational drug that selectively damages brain serotonin (5-HT) neurons in animals at doses …

Reduced striatal dopamine transporter density in abstinent methamphetamine and methcathinone users: evidence from positron emission tomography studies with …

UD McCann, DF Wong, F Yokoi… - Journal of …, 1998 - Soc Neuroscience
Methamphetamine and methcathinone are psychostimulant drugs with high potential for abuse.
In animals, methamphetamine and related drugs are known to damage brain dopamine (…

The effects of sleep deprivation on pain inhibition and spontaneous pain in women

MT Smith, RR Edwards, UD McCann… - Sleep, 2007 - academic.oup.com
Impaired central pain modulation is implicated in the pathophysiology of chronic pain. In this
controlled experiment, we evaluated whether partial sleep loss altered endogenous pain …

Memory impairment in abstinent MDMA (" Ecstasy") users

KI Bolla, UD McCann, GA Ricaurte - Neurology, 1998 - AAN Enterprises
Background: Methylenedioxymethamphetamine (MDMA, or "Ecstasy") is a popular
recreational drug of abuse that is known to damage brain serotonergic neurons in animals and …

Serotonin neurotoxicity after (±) 3, 4-methylenedioxymethamphetamine (MDMA;“Ecstasy”): a controlled study in humans

UD McCann, A Ridenour, Y Shaham… - …, 1994 - nature.com
(±) 3, 4-Methylenedioxymethamphetamine (MDMA;“Ecstasy”), an increasingly popular
recreational drug, is known to damage brain serotonin 5-hydroxytryptamine (5-HT) neurons in …

Altered serotonin innervation patterns in the forebrain of monkeys treated with (±) 3, 4-methylenedioxymethamphetamine seven years previously: factors influencing …

G Hatzidimitriou, UD McCann… - Journal of …, 1999 - Soc Neuroscience
The recreational drug (±)3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”) is a potent
and selective brain serotonin (5-HT) neurotoxin in animals and, possibly, in humans. The …