Intestinal cytochrome P450 (P450) proteins play an important role in the biotransformation
of drugs and may significantly limit their oral absorption and bioavailability. Therefore, we …

Inhibiting the interaction of menin with the histone methyltransferase MLL1 (KMT2A) has
recently emerged as a novel therapeutic strategy. Beneficial therapeutic effects have been …

Chemokines are a diverse group of small proteins that effect cell signaling by binding to G‐protein–coupled,
seven‐trans‐membrane receptors. Our group had found previously that the …

Hepatobiliary elimination via canalicular efflux transport proteins plays a key role in the
clearance of endo- and xenobiotics. Correct membrane localization and coordinated action of the …

PURPOSE: To establish a fluorescence-based assay for drug interactions with the ABC-export-protein
MRP2 (ABCC2). METHODS: Apical membrane vesicles were isolated by …

Several targeted therapeutic options exist for non-small cell lung cancer (NSCLC) patients
whose tumors harbor mutations of EGFR, including L858R, exon 19 deletions, and the …

Stroke is a very complex disease influenced by many risk factors: genetic, environmental and
comorbidities, such as hypertension, diabetes mellitus, obesity and having had a previous …

The PI3K pathway plays critical roles in cancer cell growth and survival, as well as in intrinsic
and acquired resistance to both chemotherapy and targeted agents. These essential roles …

Although targeting lipogenesis for cancer treatment appears to have a strong rationale, drug
discovery in this field has not been fully explored due to the lack of understanding the mode …

Introduction: Several generations of PI3K inhibitors have been tested in clinic. However,
thus far, clinical activity has been moderate. Different from other oral PI3K inhibitors dosed …