User profiles for Utkarsh Doshi
 | Utkarsh Doshiprincipal scientist 2 at Altria Client Services LLC Verified email at altria.com Cited by 444 |
Human enterocytes as an in vitro model for the evaluation of intestinal drug metabolism: characterization of drug-metabolizing enzyme activities of cryopreserved …
We report in this work successful isolation and cryopreservation of enterocytes from human
small intestine. The enterocytes were isolated by enzyme digestion of the intestinal lumen, …
small intestine. The enterocytes were isolated by enzyme digestion of the intestinal lumen, …
Synthesis and anticonvulsant activity of new N-1′, N-3′-disubstituted-2′ H, 3H, 5′ H-spiro-(2-benzofuran-1, 4′-imidazolidine)-2′, 3, 5′-triones
Thirteen new N-1′,N-3′-disubstituted-2′H,3H,5′H-spiro-(2-benzofuran-1,4′-imidazolidine)-2′,3,5′-triones
were synthesized and their pharmacological activity determined with …
were synthesized and their pharmacological activity determined with …
Evaluation of multiple mechanism-based toxicity endpoints in primary cultured human hepatocytes for the identification of drugs with clinical hepatotoxicity: Results …
We report here the results of a collaborative research program to develop a robust and
reliable in vitro system to allow an accurate definition of the drug-induced liver injury (DILI) …
reliable in vitro system to allow an accurate definition of the drug-induced liver injury (DILI) …
[HTML][HTML] A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was …
…, C Merg, S Frentzel, NV Ivanov, U Doshi… - Internal and Emergency …, 2019 - Springer
In the context of tobacco harm-reduction strategy, the potential reduced impact of electronic
cigarette (EC) exposure should be evaluated relative to the impact of cigarette smoke …
cigarette (EC) exposure should be evaluated relative to the impact of cigarette smoke …
Prediction of the pharmacokinetics of pravastatin as an OATP substrate using plateable human hepatocytes with human plasma data and PBPK modeling
Plateable human hepatocytes with human plasma were utilized to generate the uptake
transporter kinetic data for pravastatin, an organic anion‐transporting polypeptide (OATP) …
transporter kinetic data for pravastatin, an organic anion‐transporting polypeptide (OATP) …
In vitro evaluation of hepatotoxic drugs in human hepatocytes from multiple donors: Identification of P450 activity as a potential risk factor for drug-induced liver injuries
A possible risk factor for drug-induced hepatotoxicity is drug metabolizing enzyme activity,
which is known to vary among individuals due to genetic (genetic polymorphism) and …
which is known to vary among individuals due to genetic (genetic polymorphism) and …
Endoplasmic reticulum stress induction and ERK1/2 activation contribute to nefazodone-induced toxicity in hepatic cells
Nefazodone, an antagonist for the 5-hydroxytryptanine receptor, has been used for the treatment
of depression. Acute liver injury has been documented to be associated with the use of …
of depression. Acute liver injury has been documented to be associated with the use of …
Effects of culture duration on gene expression of P450 isoforms, uptake and efflux transporters in primary hepatocytes cultured in the absence and presence of …
We report here a comprehensive evaluation of the effects of culture duration on the gene
expression of P450 isoforms, uptake transporters and efflux transporters in human hepatocyte …
expression of P450 isoforms, uptake transporters and efflux transporters in human hepatocyte …
Luciferin IPA–based higher throughput human hepatocyte screening assays for CYP3A4 inhibition and induction
The authors report here higher throughput screening (HTS) assays for the evaluation of
CYP3A4 inhibition and CYP3A4 induction in human hepatocytes using a novel CYP3A4 …
CYP3A4 inhibition and CYP3A4 induction in human hepatocytes using a novel CYP3A4 …
Higher throughput human hepatocyte assays for the evaluation of time-dependent inhibition of CYP3A4
Time-dependent or mechanism-based CYP3A4 inhibition is an important adverse drug
property that should be carefully managed during drug development. Evaluation of time-…
property that should be carefully managed during drug development. Evaluation of time-…