Metformin is the most commonly used treatment to increase insulin sensitivity in insulin-resistant
(IR) conditions such as diabetes, prediabetes, polycystic ovary syndrome, and obesity. …

Alcohol use disorder (AUD) is a highly prevalent, comorbid, and disabling disorder. The
underlying mechanism of ethanol neurotoxicity and the involvement of oxidative stress is still not …

Background The benefit of pharmacogenetic testing before starting drug therapy has been
well documented for several single gene–drug combinations. However, the clinical utility of a …

Diabetic kidney disease (DKD) is a severe and common complication and affects a quarter
of patients with type 2 diabetes mellitus (T2DM). Oxidative stress and inflammation related to …

Despite scientific and clinical advances in the field of pharmacogenomics (PGx), application
into routine care remains limited. Opportunely, several implementation studies and …

Objective Methotrexate (MTX) is a disease-modifying antirheumatic drug used in the treatment
of rheumatoid arthritis (RA). Genetic polymorphisms of reduced folate carrier (RFC1 A80G)…

Purpose The objectives of this study were (1) to develop a population pharmacokinetic
model of high-dose methotrexate (HD-MTX) in children with acute lymphoblastic leukaemia (ALL) …

Objective To analyze the mutational spectrum of steroid 21-hydroxylase (CYP21) and the
genotype– phenotype correlation in patients with congenital adrenal hyperplasia (CAH) …

Objective Leflunomide is a disease-modifying antirheumatic drug used for treating
rheumatoid arthritis (RA). In vitro studies demonstrated that cytochromes P450 (CYPs), mainly …

Objective To address the role of translationally active HIV reservoir in chronic inflammation
and non-AIDS related disorders, we first need a simple and accurate assay to evaluate viral …