Synthetic routes to a series of mono- and difluorinated 2-(4-amino-3-substituted-phenyl)benzothiazoles
have been devised. Whereas mixtures of regioisomeric 5- and 7-fluoro-…

Despite the key role of magnesium in many fundamental biological processes, knowledge
about its intracellular regulation is still scarce, due to the lack of appropriate detection methods…

There is an unsettled debate about the role of magnesium as a ‘chronic regulator’ of biological
functions, as opposed to the well-known role for calcium as an ‘acute regulator’. New and …

Purpose In less than one and a half year, the COVID-19 pandemic has nearly brought to a
collapse our health care and economic systems. The scientific research community has …

Low magnesium (Mg) has been associated with oxidative stress, an important player in
aging, atherosclerosis and other vascular diseases. In vivo, low Mg and immune system …

2-(4-Amino-3-methylphenyl) benzothiazole (NSC 674495; DF 203) demonstrates drug uptake
and metabolism by tumor cells sensitive to the antiproliferative activity of the drug [J Med …

A wide variety of biochemical reactions and physiological functions are known to require
magnesium; nonetheless, its regulatory mechanisms (both at the cellular and systemic level) …

The relationship between magnesium and cancer is not as simple as could be assumed
from the well-established requirement of magnesium for cell proliferation. Basic and pre-clinical …

Neoplastic cells accumulate magnesium, an event which provides selective advantages
and is frequently associated with TRPM7overexpression. Little is known about magnesium …

Derangement of magnesium homeostasis underlies the pathophysiology of many diseases,
including cancer. Recent advances support the view that aberrant expression of Mg 2+ …