Role of hepatic and intestinal p450 enzymes in the metabolic activation of the colon carcinogen azoxymethane in mice
V Megaraj, X Ding, C Fang, N Kovalchuk… - Chemical research in …, 2014 - ACS Publications
P450-mediated bioactivation of azoxymethane (AOM), a colon carcinogen, leads to the
formation of DNA adducts, of which O 6 -methylguanine (O 6 -mG) is the most mutagenic and …
formation of DNA adducts, of which O 6 -methylguanine (O 6 -mG) is the most mutagenic and …
Rates of substance and polysubstance use through universal maternal testing at the time of delivery
…, MP Marcotte, KDR Setchell, V Megaraj… - Journal of …, 2022 - nature.com
Objective To report substance and polysubstance use at the time of delivery. Study design A
cross-sectional study was performed on mothers consented for universal drug testing (99%) …
cross-sectional study was performed on mothers consented for universal drug testing (99%) …
Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo …
V Megaraj, X Zhou, F Xie, Z Liu, W Yang… - …, 2014 - academic.oup.com
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK),
which is abundant in tobacco smoke, is a potent lung procarcinogen. The present study was …
which is abundant in tobacco smoke, is a potent lung procarcinogen. The present study was …
Stable-isotope dilution HPLC–electrospray ionization tandem mass spectrometry method for quantifying hydroxyurea in dried blood samples
A Marahatta, V Megaraj, PT McGann, RE Ware… - Clinical …, 2016 - academic.oup.com
BACKGROUND Sickle cell anemia (SCA) is a life-threatening blood disorder characterized
by the presence of sickle-shaped erythrocytes. Hydroxyurea is currently the only US Food …
by the presence of sickle-shaped erythrocytes. Hydroxyurea is currently the only US Food …
Identification of cytochrome P450 enzymes critical for lung tumorigenesis by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) …
L Li, V Megaraj, Y Wei, X Ding - Carcinogenesis, 2014 - academic.oup.com
Cytochrome P450 (P450) enzymes encoded by the mouse Cyp2abfgs gene cluster are
preferentially expressed in the respiratory tract. Previous studies have demonstrated that …
preferentially expressed in the respiratory tract. Previous studies have demonstrated that …
Human multidrug resistance protein 2 transports the therapeutic bile salt tauroursodeoxycholate
PM Gerk, W Li, V Megaraj, M Vore - Journal of Pharmacology and …, 2007 - ASPET
The multidrug resistance protein 2 (MRP2/ABCC2) mediates the biliary excretion of glucuronide
and glutathione conjugates of endogenous and exogenous compounds. We examined …
and glutathione conjugates of endogenous and exogenous compounds. We examined …
Functional analysis of nonsynonymous single nucleotide polymorphisms of multidrug resistance-associated protein 2 (ABCC2)
V Megaraj, T Zhao, CM Paumi, PM Gerk… - Pharmacogenetics …, 2011 - journals.lww.com
Background Multidrug resistance-associated protein 2 (MRP2; ABCC2) mediates the biliary
excretion of glutathione, glucuronide, and sulfate conjugates of endobiotics and xenobiotics. …
excretion of glutathione, glucuronide, and sulfate conjugates of endobiotics and xenobiotics. …
Hepatobiliary disposition of 3α, 6α, 7α, 12α-tetrahydroxy-cholanoyl taurine: a substrate for multiple canalicular transporters
V Megaraj, T Iida, P Jungsuwadee, AF Hofmann… - Drug metabolism and …, 2010 - ASPET
Tetrahydroxy bile acids become major biliary bile acids in Bsep(−/−) mice and Fxr(−/−) mice
fed cholic acid; we characterized disposition of these novel bile acids that also occur in …
fed cholic acid; we characterized disposition of these novel bile acids that also occur in …
Suppression of pulmonary CYP2A13 expression by carcinogen-induced lung tumorigenesis in a CYP2A13-humanized mouse model
Z Liu, V Megaraj, L Li, S Sell, J Hu, X Ding - Drug Metabolism and …, 2015 - ASPET
CYP2A13 is a human cytochrome P450 (P450) enzyme important in the bioactivation of the
tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). …
tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). …
Regional comparison of self-reported late pregnancy cigarette smoking to mass spectrometry analysis
…, EA Kelly, KDR Setchell, V Megaraj… - Journal of …, 2021 - nature.com
Objective To report a more accurate prevalence estimate of late pregnancy nicotine exposures.
Study design A cross-sectional study during a 2-month period in 2019. Participants were …
Study design A cross-sectional study during a 2-month period in 2019. Participants were …