Human UDP-glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and …
V Uchaipichat, PI Mackenzie, XH Guo… - Drug Metabolism and …, 2004 - ASPET
The glucuronidation kinetics of the prototypic substrates 4-methylumbelliferone (4MU) and 1-naphthol
(1NP) by human UDP-glucuronosyltransferases (UGT) 1A1, 1A3, 1A4, 1A6, 1A7, …
(1NP) by human UDP-glucuronosyltransferases (UGT) 1A1, 1A3, 1A4, 1A6, 1A7, …
Selectivity of substrate (trifluoperazine) and inhibitor (amitriptyline, androsterone, canrenoic acid, hecogenin, phenylbutazone, quinidine, quinine, and sulfinpyrazone)“ …
V Uchaipichat, PI Mackenzie, DJ Elliot… - Drug metabolism and …, 2006 - ASPET
Relatively few selective substrate and inhibitor probes have been identified for human UDP-glucuronosyltransferases
(UGTs). This work investigated the selectivity of trifluoperazine (…
(UGTs). This work investigated the selectivity of trifluoperazine (…
Quantitative prediction of in vivo inhibitory interactions involving glucuronidated drugs from in vitro data: the effect of fluconazole on zidovudine glucuronidation
V Uchaipichat, LK Winner, PI Mackenzie… - British journal of …, 2006 - Wiley Online Library
Aims Using the fluconazole–zidovudine (AZT) interaction as a model, to determine whether
inhibition of UDP–glucuronosyltransferase (UGT) catalysed drug metabolism in vivo could …
inhibition of UDP–glucuronosyltransferase (UGT) catalysed drug metabolism in vivo could …
In vitro–in vivo extrapolation predicts drug–drug interactions arising from inhibition of codeine glucuronidation by dextropropoxyphene, fluconazole, ketoconazole, and …
P Raungrut, V Uchaipichat, DJ Elliot… - … of Pharmacology and …, 2010 - ASPET
Because codeine (COD) is eliminated primarily via glucuronidation, factors that alter COD
glucuronide formation potentially affect the proportion of the dose converted to the …
glucuronide formation potentially affect the proportion of the dose converted to the …
Relationship between hyperbilirubinaemia and UDP-glucuronosyltransferase 1A1 (UGT1A1) polymorphism in adult HIV-infected Thai patients treated with indinavir
…, PI Mackenzie, V Uchaipichat… - Pharmacogenetics …, 2006 - journals.lww.com
Objectives To investigate the association between the UGT1A1* 6 (G71R) and UGT1A1* 28
(promoter (TA) 7-repeat) genotypes and hyperbilirubinaemia in Thai patients treated with …
(promoter (TA) 7-repeat) genotypes and hyperbilirubinaemia in Thai patients treated with …
Kinetic modeling of the interactions between 4-methylumbelliferone, 1-naphthol, and zidovudine glucuronidation by UDP-glucuronosyltransferase 2B7 (UGT2B7) …
V Uchaipichat, A Galetin, JB Houston… - Molecular …, 2008 - ASPET
Interactions between the UGT2B7-catalyzed glucuronidation of zidovudine (AZT), 4-methylumbelliferone
(4MU), and 1-naphthol (1NP) were analyzed using multisite and empirical …
(4MU), and 1-naphthol (1NP) were analyzed using multisite and empirical …
The glucuronidation of R-and S-lorazepam: human liver microsomal kinetics, UDP-glucuronosyltransferase enzyme selectivity, and inhibition by drugs
V Uchaipichat, C Suthisisang, JO Miners - Drug Metabolism and Disposition, 2013 - ASPET
The widely used hypnosedative-anxiolytic agent R,S-lorazepam is cleared predominantly
by conjugation with glucuronic acid in humans, but the enantioselective glucuronidation of …
by conjugation with glucuronic acid in humans, but the enantioselective glucuronidation of …
Effects of ketamine on human UDP-glucuronosyltransferases in vitro predict potential drug-drug interactions arising from ketamine inhibition of codeine and morphine …
V Uchaipichat, P Raungrut, N Chau… - Drug metabolism and …, 2011 - ASPET
In this study, the selectivity of UDP-glucuronosyltransferase (UGT) enzyme inhibition by
ketamine (KTM) and the kinetics of KTM inhibition of human liver microsomal morphine (MOR) …
ketamine (KTM) and the kinetics of KTM inhibition of human liver microsomal morphine (MOR) …
In vitro–in vivo extrapolation of CYP2C8-catalyzed paclitaxel 6α-hydroxylation: Effects of albumin on in vitro kinetic parameters and assessment of interindividual …
…, TM Polasek, TM Heath, V Uchaipichat… - European journal of …, 2011 - Springer
Objectives This study aimed to characterize the effects of bovine serum albumin (BSA) on
the kinetics of CYP2C8-catalyzed paclitaxel 6α-hydroxylation in vitro; determine whether the …
the kinetics of CYP2C8-catalyzed paclitaxel 6α-hydroxylation in vitro; determine whether the …
A qualitative study to explore how patients identify and assess symptoms as adverse drug reactions
…, J Krska, T Pratipanawatr, V Uchaipichat… - European journal of …, 2014 - Springer
Purpose To explore how Thai patients assess symptoms as adverse drug reactions (ADRs).
Methods Out-patients at two hospitals in Thailand previously reporting suspected ADRs to …
Methods Out-patients at two hospitals in Thailand previously reporting suspected ADRs to …