The study herein determined the role of nuclear factor erythoid 2–related factor 2 (Nrf2) in the
pathogenesis of hepatic steatosis, insulin resistance, obesity, and type 2 diabetes. Lep ob/…

The UDP-glucuronosyltransferases (UGTs) and sulfotransferases (SULTs) represent major
phase II drug-metabolizing enzymes that are also responsible for maintaining cellular …

Background: Exposure to chemicals during critical windows of development may re-program
liver for increased risk of nonalcoholic fatty liver disease (NAFLD). Bisphenol A (BPA), a …

Lipid sensor peroxisome proliferator-activated receptor alpha (PPAR-α) is the master regulator
of lipid metabolism. Dietary release of endogenous free fatty acids, fibrates, and certain …

The nuclear factor E2-related factor 2 (Nrf2)–Kelch-like ECH-associated protein 1 (Keap1)
pathway upregulates antioxidant and biotransformation enzyme expression to counter cellular …

Unsafe use of alcohol results in approximately 2.5 million deaths worldwide, with cirrhosis
contributing to 16.6% of reported deaths. Serum insulin levels are often elevated in alcoholism …

Drug pharmacokinetics can be altered in obese and diabetic subjects. In consideration of
the prevalence of obesity and diabetes, characterization of transporter expression in mouse …

Objective To evaluate whether Nrf2 deficiency impacts insulin resistance and lipid
accumulation in liver and white adipose tissue. Methods Lep ob/ob mice (OB) with targeted Nrf2 …

Deltamethrin, a type II pyrethroid, is a widely used insecticide. The purpose of this study was
to determine whether perinatal deltamethrin exposure altered the expression of adipogenic …

Background Type-2 Diabetes is a major health concern in the United States and other
Westernized countries, with prevalence increasing yearly. There is a need to better model and …