Rodent models of depression: forced swim and tail suspension behavioral despair tests in rats and mice
V Castagné, P Moser, S Roux… - Current protocols in …, 2010 - Wiley Online Library
The development of antidepressants requires simple rodent behavioral tests for initial screening
before undertaking more complex preclinical tests and clinical evaluation. Presented in …
before undertaking more complex preclinical tests and clinical evaluation. Presented in …
[PDF][PDF] Hepatic resection after rescue cetuximab treatment for colorectal liver metastases previously refractory to conventional systemic therapy
…, D Machover, M Ducreux, V Castagne… - J Clin …, 2007 - researchgate.net
Purpose In patients with unresectable colorectal liver metastases (CLM) resistant to first-line
chemotherapy, the impact of cetuximab therapy on resectability is unknown. This study was …
chemotherapy, the impact of cetuximab therapy on resectability is unknown. This study was …
Use of latency to immobility improves detection of antidepressant-like activity in the behavioral despair test in the mouse
V Castagné, RD Porsolt, P Moser - European journal of pharmacology, 2009 - Elsevier
The behavioral despair test (BDT), also called the forced swim test, is an economic, reliable
and sensitive test for the detection of potential antidepressant-like activity of new test …
and sensitive test for the detection of potential antidepressant-like activity of new test …
Relationships between neuronal death and the cellular redox status. Focus on the developing nervous system
V Castagne, M Gautschi, K Lefevre, A Posada… - Progress in …, 1999 - Elsevier
During the development of the nervous system, a large number of neurons are eliminated
through naturally occurring neuronal death. Many morphological and biochemical properties …
through naturally occurring neuronal death. Many morphological and biochemical properties …
Behavioral indices in antipsychotic drug discovery
RD Porsolt, PC Moser, V Castagné - Journal of Pharmacology and …, 2010 - ASPET
Schizophrenia is characterized by three major symptom classes: positive symptoms, negative
symptoms, and cognitive deficits. Classical antipsychotics (phenothiazines, thioxanthenes, …
symptoms, and cognitive deficits. Classical antipsychotics (phenothiazines, thioxanthenes, …
[HTML][HTML] Behavioral assessment of antidepressant activity in rodents
V Castagné, P Moser, RD Porsolt - 2011 - europepmc.org
Depression is one of several disorders affecting mood, along with mania, hypomania, and
bipolar disorders. The present chapter focuses on behavioral assessment of antidepressant …
bipolar disorders. The present chapter focuses on behavioral assessment of antidepressant …
Comparison of methods for the assessment of locomotor activity in rodent safety pharmacology studies
JJ Lynch III, V Castagné, PC Moser… - … of pharmacological and …, 2011 - Elsevier
INTRODUCTION: General neurobehavioral assays, like a modified Irwin test or a functional
observational battery, are necessary for central nervous system (CNS) safety pharmacology …
observational battery, are necessary for central nervous system (CNS) safety pharmacology …
Low brain glutathione and ascorbic acid associated with dopamine uptake inhibition during rat's development induce long-term cognitive deficit: relevance to …
V Castagné, M Rougemont, M Cuenod, KQ Do - Neurobiology of disease, 2004 - Elsevier
Schizophrenia is associated with a cerebral glutathione deficit, which may leave the brain
susceptible to oxidants. To study the consequences of a glutathione deficit, we treated …
susceptible to oxidants. To study the consequences of a glutathione deficit, we treated …
Introduction to the EQIPD quality system
…, R Bernard, A Gilis, B Gerlach, J Guillen, V Castagne… - Elife, 2021 - elifesciences.org
While high risk of failure is an inherent part of developing innovative therapies, it can be
reduced by adherence to evidence-based rigorous research practices. Supported through the …
reduced by adherence to evidence-based rigorous research practices. Supported through the …
[HTML][HTML] Anti-CTLA-4 and anti-PD-1 immunotherapies repress tumor progression in preclinical breast and colon model with independent regulatory T cells response
…, C Legrand, M Hunault, G Froget, V Castagné - Translational …, 2022 - Elsevier
The recent development of immunotherapy represents a significant breakthrough in cancer
therapy. Several immunotherapies provide robust efficacy gains in a wide variety of cancers. …
therapy. Several immunotherapies provide robust efficacy gains in a wide variety of cancers. …