CRISPR-Cas RNA-guided endonucleases hold great promise for disrupting or correcting
genomic sequences through site-specific DNA cleavage and repair. However, the lack of …

Compound 4 (PF-04971729) belongs to a new class of potent and selective sodium-dependent
glucose cotransporter 2 inhibitors incorporating a unique dioxa-bicyclo[3.2.1]octane (…

The development of a gold(I)‐catalyzed sulfination of aryl boronic acids is described. This
transformation proceeds through an unprecedented mechanism which exploits the reactivity of …

A palladium‐catalyzed one‐step synthesis of (hetero)aryl alkyl sulfones from (hetero)arylboronic
acids, potassium metabisulfite, and unactivated or activated alkylhalides is described. …

The first total synthesis of (±)-pentacycloanammoxic acid/methyl ester (1), an unusual naturally
occurring fatty acid from Candidatus Brocadia anammoxidans, has been accomplished …

A highly effective enantioselective synthesis of pentacycloanammoxic acid (1), an unusual
naturally occurring fatty acid from Candidatus Brocadia anammoxidans, has been …

The disposition of ertugliflozin (PF-04971729), an orally active selective inhibitor of the
sodium-dependent glucose cotransporter 2, was studied after a single 25-mg oral dose of [ 14 C]-…

Preclinical drug metabolism studies play a key role in the lead identification and optimization
process in drug discovery. Characterization of the metabolic pathways of new chemical …

Cyclic constraints are incorporated into an 11-residue analogue of the N-terminus of
glucagon-like peptide-1 (GLP-1) to investigate effects of structure on agonist activity. Cyclization …

A novel palladium-catalyzed sulfination of aryl and heteroaryl halides is described. This
reaction operates under mild conditions and provides access to a wide range of aryl and …