A novel trehalase from Mycobacterium smegmatis − purification, properties, requirements
JD Carroll, I Pastuszak, VK Edavana, YT Pan… - The FEBS …, 2007 - Wiley Online Library
Trehalose is a nonreducing disaccharide of glucose (α,α‐1,1‐glucosyl‐glucose) that is
essential for growth and survival of mycobacteria. These organisms have three different …
essential for growth and survival of mycobacteria. These organisms have three different …
Trehalose synthase converts glycogen to trehalose
…, N Asano, I Pastuszak, VK Edavana… - The FEBS …, 2008 - Wiley Online Library
Trehalose (α,α‐1,1‐glucosyl‐glucose) is essential for the growth of mycobacteria, and these
organisms have three different pathways that can produce trehalose. One pathway involves …
organisms have three different pathways that can produce trehalose. One pathway involves …
[HTML][HTML] Fulvestrant up regulates UGT1A4 and MRP s through ERα and c-Myb pathways: a possible primary drug disposition mechanism
VK Edavana, RB Penney, A Yao-Borengasser… - Springerplus, 2013 - Springer
Fulvestrant (Faslodex™) is a pure antiestrogen that is effective in treating estrogen receptor-(ER)
positive breast cancer tumors that are resistant to selective estrogen receptor …
positive breast cancer tumors that are resistant to selective estrogen receptor …
[HTML][HTML] Sulfotransferase 1A1 (SULT1A1) gene expression is regulated by members of the NFI transcription factors in human breast cancer cells
A Yao-Borengasser, LJ Rogers, VK Edavana… - BMC clinical …, 2014 - Springer
Background Sulfotransferase 1A1 (SULT1A1) gene expression is tissue specific, with little
to no expression in normal breast epithelia. Expression in breast tumors has been …
to no expression in normal breast epithelia. Expression in breast tumors has been …
A potential role for human UDP-glucuronosyltransferase 1A4 promoter single nucleotide polymorphisms in the pharmacogenomics of tamoxifen and its derivatives
AK Greer, A Starlard-Davenport, VK Edavana… - Drug Metabolism and …, 2014 - ASPET
Tamoxifen (Tam) is a selective estrogen receptor modulator used to inhibit breast tumor
growth. Tam can be directly N-glucuronidated via the tertiary amine group or O-glucuronidated …
growth. Tam can be directly N-glucuronidated via the tertiary amine group or O-glucuronidated …
CYP19A1 single nucleotide polymorphism associations with CYP19A1, NFκB1, and IL6 gene expression in human normal colon and normal liver samples
…, A Yao-Borengasser, VK Edavana… - Pharmacogenomics …, 2014 - Taylor & Francis
Background Estrogen is known to decrease the risk of colon cancer in postmenopausal women,
and may exert its actions by decreasing interleukin-6 (IL6) production via stabilization of …
and may exert its actions by decreasing interleukin-6 (IL6) production via stabilization of …
Identification of human nuclear factor 1 (NF-1) as a potential transcription factor which regulates the gene expression of Sulfotransferase isoform 1A1 (SULT1A1) in …
A Yao-Borengasser, X Yu, IB Dhakal, VK Edavana… - Cancer Research, 2012 - AACR
Sulfotransferase isoform 1A1 (SULT1A1) plays a central role in drug metabolism. SULT1A1
expression is tissue specific, with little to no expression in normal breast epithelia but …
expression is tissue specific, with little to no expression in normal breast epithelia but …
[PDF][PDF] A potential role for human UDP-glucuronosyltransferase (UGT) 1A4 promoter SNPs in the pharmacogenomics of tamoxifen and its derivatives
AK Greer, A Starlard-Davenport, VK Edavana… - Drug Metabolism and …, 2014 - Citeseer
DMD# 58016 Abstract Tamoxifen (Tam) is a selective estrogen receptor (ER) modulator used
to inhibit breast tumor growth. Tam can be directly N-glucuronidated via the tertiary amine …
to inhibit breast tumor growth. Tam can be directly N-glucuronidated via the tertiary amine …
Potential role of UGT1A4 promoter SNPs in anastrozole pharmacogenomics
VK Edavana, IB Dhakal, S Williams, R Penney… - Drug Metabolism and …, 2013 - ASPET
Anastrozole belongs to the nonsteroidal triazole-derivative group of aromatase inhibitors.
Recently, clinical trials demonstrated improved antitumoral efficacy and a favorable toxicity …
Recently, clinical trials demonstrated improved antitumoral efficacy and a favorable toxicity …
Cloning and expression of the trehalose-phosphate phosphatase of Mycobacterium tuberculosis: comparison to the enzyme from Mycobacterium smegmatis
VK Edavana, I Pastuszak, JD Carroll, P Thampi… - Archives of biochemistry …, 2004 - Elsevier
Two open reading frames in the Mycobacterium tuberculosis genome, Rv3372 and Rv2006,
have about 25% sequence identity at the amino acid level to the trehalose-phosphate …
have about 25% sequence identity at the amino acid level to the trehalose-phosphate …