The pathogenesis of transmissible encephalopathies is associated with the conversion of the
cellular prion protein, PrP C, into a conformationally altered oligomeric form, PrP Sc. Here …

The clinical importance of fibrin stabilizing factor ago, when Barkan and Gaspar [1] demonbecame
apparent when in 1960 Duckert and colstrated that fibrin clots that were formed in the …

Mechanical stability in many biological materials is provided by the crosslinking of large
structural proteins with gamma-glutamyl-epsilon-lysyl amide bonds. The three-dimensional …

Background: Blood coagulation occurs by a cascade of zymogen activation resulting from
minor proteolysis. The final stage of coagulation involves thrombin generation and limited …

2′-5′-oligoadenylate synthetases are interferon-induced, double-stranded RNA-activated
antiviral enzymes which are the only proteins known to catalyze 2′-specific nucleotidyl …

Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs.
Genetic polymorphisms for TPMT are a major factor responsible for large individual variations in …

A conformational transition of normal cellular prion protein (PrP C ) to its pathogenic form (PrP
Sc ) is believed to be a central event in the transmission of the devastating neurological …

The X‐ray crystal structure of human transglutaminase factor XIII has revealed a cysteine
proteinase‐like active site involved in a crosslinking reaction and not proteolysis. This is among …

The interaction of leukocyte integrin α M β 2 (CD11b/CD18, Mac-1) with fibrinogen has
been implicated in the inflammatory response by contributing to leukocyte adhesion to the …

The atrial natriuretic peptide (ANP) hormone is secreted by the heart in response to an
increase in blood pressure. ANP exhibits several potent anti-hypertensive actions in the kidney, …