… pooled to generate a plasma pool. The levels of radioactivity in … percentage weight basis to
generate a urine pool (10 ml). Each … weight basis to generate a homogenate pool (2 ml). Each …

Troglitazone (TGZ), the first glitazone used for the treatment of type II diabetes mellitus and
removed from the market for liver toxicity, was shown to bind covalently to microsomal protein …

The clinical use of carbamazepine (CBZ), an anticonvulsant, is associated with a variety of
idiosyncratic adverse reactions that are likely related to the formation of chemically reactive …

1. Tacrine (1,2,3,4‐tetrahydro‐9‐aminoacridine‐hydrochloride: THA) underwent metabolism
in vitro by a panel (n = 12) of human liver microsomes genotyped for CYP2D6, in the …

Tacrine (1,2,3,4-tetrahydro-9-aminoacridine hydrochloride; THA) is known to undergo
extensive oxidative metabolism to a variety of mono- and dihydroxylated metabolites in animals …

Tacrine's [1,2,3,4-tetrahydro-9-acridinamine monohydrochloride monohydrate, (THA)] metabolic
fate was examined using human and rat liver microsomal preparations. Following 1-hr …

1. The metabolite profile of tacrine (1,2,3,4-tetrahydro-9-amino acridine) was similar in hepatic
microsomes from man, rat, dog, rabbit, mouse and hamster. Major metabolites were 1-, 2-, …

… pooled on a percent weight basis to generate a urine pool (2 ml). After centrifugation, each
… on a percent weight basis to generate a homogenate pool (2 ml). Each pooled sample was …

N'-Oxidation of nicotine isomers by porcine liver flavin-containing monooxygenase shows a
clear stereoselectivity in the formation of the diastereomeric N'-oxides. (S)-(-)-Nicotine …

The potential role of oxidative metabolism in tacrine (1, 2, 3, 4-tetrahydro-9-amino acridine)-induced
transaminitis has been investigated in an in vitro system. In the presence of human …