[PDF][PDF] Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3).

SA Wrighton, WR Brian, MA Sari, M Iwasaki… - Molecular …, 1990 - Citeseer
The human P450111 family has been shown to be composed of at least four members,
P450I1IA3 (HLp), P450II1A4(P45ONF), P45OlIlA5(HLp3), and P450I1IA6(HLp2). Due to the lack …

Oxidation of dihydropyridine calcium channel blockers and analogs by human liver cytochrome P-450 IIIA4

FP Guengerich, WR Brian, M Iwasaki… - Journal of medicinal …, 1991 - ACS Publications
A series of 21 different 4-substituted 2, 6-dimethyl-3-(alkoxycarbonyl)-l, 4-dihydropyridines
was considered with regard to oxidation to pyridine derivatives by human liver microsomal …

Pharmacokinetic assessment of a five‐probe cocktail for CYPs 1A2, 2C9, 2C19, 2D6 and 3A

S Turpault, W Brian, R Van Horn… - British journal of …, 2009 - Wiley Online Library
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Numerous cocktails using concurrent
administration of several cytochrome P450 (CYP) isoform‐selective probe drugs have …

Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae

WR Brian, MA Sari, M Iwasaki, T Shimada… - Biochemistry, 1990 - ACS Publications
Revised Manuscript Received July 18, 1990 abstract: A human liver cytochromeP-450 (P-450)
IIIA4 cDNA clone was inserted behind an alcohol dehydrogenase promoter in the plasmid …

Metabolomic and genome‐wide association studies reveal potential endogenous biomarkers for OATP1B1

…, A Coelho, AA Zur, K Mertsch, W Brian… - Clinical …, 2016 - Wiley Online Library
Transporter‐mediated drug‐drug interactions (DDIs) are a major cause of drug toxicities.
Using published genome‐wide association studies (GWAS) of the human metabolome, we …

Effects of gibberellins on plant growth and development

PW Brian - Biological reviews, 1959 - Wiley Online Library
… growth rate and the magnitude of the response to GA is strictly quantitative (Brian & … grew
no faster than those of a dwarf variety (Brian & Hemming, unpublished results), whereas intact …

Endothelial tubes assemble from intracellular vacuoles in vivo

M Kamei, W Brian Saunders, KJ Bayless, L Dye… - Nature, 2006 - nature.com
The formation of epithelial tubes is crucial for the proper development of many different tissues
and organs, and occurs by means of a variety of different mechanisms 1 . Morphogenesis …

Long-runout rockfalls

W Brian Dade, HE Huppert - Geology, 1998 - pubs.geoscienceworld.org
Large rockfalls and debris avalanches constitute spectacular geologic hazards. A physical
basis for the prediction of the extent of runout of such transport events has remained elusive. …

Surface self-diffusion of an organic glass

L Zhu, CW Brian, SF Swallen, PT Straus, MD Ediger… - Physical Review Letters, 2011 - APS
Surface self-diffusion has been measured for an organic glass for the first time. The flattening
of 1000 nm surface gratings of liquid indomethacin occurs by viscous flow at 12 K or more …

Gliotoxin, a fungistatic metabolic product of Trichoderma viride

PW Brian, HG Hemming - Annals of Applied Biology, 1945 - Wiley Online Library
Gliotoxin is shown to be a metabolic product of Trichoderma viride, and a semi‐continuous
apparatus for its production is described. Ammonia nitrogen is preferable to nitrate nitrogen, …