[HTML][HTML] Cytochrome P450 27C1 level dictates lung cancer tumorigenicity and sensitivity towards multiple anticancer agents and its potential interplay with the IGF-1R …

…, XY Zhao, D Guo, J Han, W Noracharttiyapot… - International Journal of …, 2022 - mdpi.com
Cytochrome P450 enzymes (CYP450s) exert mighty catalytic actions in cellular metabolism
and detoxication, which play pivotal roles in cell fate determination. Preliminary data shows …

Construction of several human-derived stable cell lines displaying distinct profiles of CYP3A4 induction

W Noracharttiyapot, Y Nagai, T Matsubara… - Drug metabolism and …, 2006 - Elsevier
Cell lines which stably express reporter proteins through CYP3A4 gene activation have been
developed for use in predicting CYP3A4 induction. Twelve clones showing distinct profiles …

Assessment of human pregnane X receptor involvement in pesticide-mediated activation of CYP3A4 gene

T Matsubara, W Noracharttiyapot, T Toriyabe… - Drug metabolism and …, 2007 - ASPET
Assessment of foreign chemical inducibility on CYP3A4 is necessary to optimize drug
therapies. The properties of chemicals such as pesticides, however, are not well investigated. In …

[CITATION][C] Development of a gene-reporter assay system for evaluation of CYP3A4 inducibility of chemical

W Noracharttiyapot - 2006 - ci.nii.ac.jp
Noracharttiyapot, Wachiraporn ノラチャティティヤポット, ワチラポーン … Noracharttiyapot,
Wachiraporn ノラチャティティヤポット, ワチラポーン … Noracharttiyapot, Wachiraporn …

Polycyclic aromatic hydrocarbons activate CYP3A4 gene transcription through human pregnane X receptor

T Kumagai, H Suzuki, T Sasaki, S Sakaguchi… - Drug metabolism and …, 2012 - Elsevier
Aryl hydrocarbon receptor (AhR) activators have been shown to induce members of the
cytochrome P450 (P450) 1 family. Here we demonstrate that the AhR activators induce CYP3A4 …

CYP3A4 induction mechanism of polycyclic aromatic hydrocarbons differs from that of rifampicin in PXR binding element

Y Aratsu, R Odagiri, R Shoji, K Watanabe… - Fundamental …, 2017 - jstage.jst.go.jp
CYP3A4 is an important drug-metabolizing enzyme induced by various compounds causing
drug-drug interactions. However, the molecular mechanism of CYP3A4 induction is not …

Unveiling a new essential cis element for the transactivation of the CYP3A4 gene by xenobiotics

T Toriyabe, K Nagata, T Takada, Y Aratsu… - Molecular …, 2009 - ASPET
Pregnane X receptor (PXR) has been shown to form a heterodimer with retinoid X receptor
α (RXRα) and to bind to the distal nuclear receptor-binding element 1 and an everted repeat …

Indirubin, a component of Ban-Lan-Gen, activates CYP3A4 gene transcription through the human pregnane X receptor

T Kumagai, Y Aratsu, R Sugawara, T Sasaki… - Drug metabolism and …, 2016 - Elsevier
Ban-Lan-Gen is the common name for the dried roots of indigo plants, including Polygonum
tinctorium, Isatis indigotica, Isatis tinctoria, and Strobilanthes cusia. Ban-Lan-Gen is …

Role of human hepatocyte nuclear factor 4α in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small …

Y Kamiyama, T Matsubara, K Yoshinari… - Drug metabolism and …, 2007 - jstage.jst.go.jp
Hepatocyte nuclear factor 4a (HNF4a) is an important transcription factor in hepatic gene
expression. Here, we have investigated the role of HNF4a in the expression of drug-…

PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinone IIA

C Yu, S Ye, H Sun, Y Liu, L Gao, C Shen… - Chemico-biological …, 2009 - Elsevier
Danshen (Radix Salvia miltiorrhiza) is a famous Traditional Chinese Medicine used widely
for the treatment of coronary heart disease and cerebrovascular disease. Diterpenoid …