Development of the renal glucose reabsorption inhibitors: a new mechanism for the pharmacotherapy of diabetes mellitus type 2

WN Washburn - Journal of medicinal chemistry, 2009 - ACS Publications
Washburn received his Ph.D. in Organic Chemistry in 1971 from Columbia University,
studying non-… Washburn’s focus has been programs pertaining to obesity and type 2 diabetes. …

Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes

…, OP Flint, JM Whaley, WN Washburn - Journal of medicinal …, 2008 - ACS Publications
The C-aryl glucoside 6 (dapagliflozin) was identified as a potent and selective hSGLT2 inhibitor
which reduced blood glucose levels in a dose-dependent manner by as much as 55% in …

Evolution of sodium glucose co-transporter 2 inhibitors as anti-diabetic agents

WN Washburn - Expert Opinion on Therapeutic Patents, 2009 - Taylor & Francis
Background: A critical factor for maintenance of glucose balance is the renal recovery of
glucose from the glomerular filtrate mediated primarily by sodium glucose co-transporter 2 (…

Differentiating sodium-glucose co-transporter-2 inhibitors in development for the treatment of type 2 diabetes mellitus

WN Washburn, SM Poucher - Expert Opinion on Investigational …, 2013 - Taylor & Francis
W Washburn is an employee and shareholder of Bristol-Myers Squibb and S Poucher was
an employee of AstraZeneca during the development of this article and is a shareholder of …

Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats

…, W Meng, SA Biller, JR Wetterau, WN Washburn… - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—The inhibition of gut and renal sodium-glucose cotransporters (SGLTs) has
been proposed as a novel therapeutic approach to the treatment of diabetes. We have …

Impact of portable normothermic blood-based machine perfusion on outcomes of liver transplant: the OCS liver PROTECT randomized clinical trial

…, FG Cigarroa, JD Eason, S Syed, WK Washburn… - JAMA …, 2022 - jamanetwork.com
Importance Ischemic cold storage (ICS) of livers for transplant is associated with serious
posttransplant complications and underuse of liver allografts. Objective To determine whether …

Remote oxidation of steroids by photolysis of attached benzophenone groups

…, P Kalicky, S Liu, W Washburn - Journal of the …, 1973 - ACS Publications
Steroid esters of benzophenonecarboxylic acids, benzophenoneacetic acids, and homologs
are prepared. Circular dichroism studies indicatethat in some of these compounds the …

In vitro characterization and pharmacokinetics of dapagliflozin (BMS-512148), a potent sodium-glucose cotransporter type II inhibitor, in animals and humans

…, L Discenza, W Washburn, W Meng… - Drug metabolism and …, 2010 - ASPET
(2S,3R,4R,5S,6R)-2-(3-(4-Ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyl-tetrahydro-2H-pyran-3,4,5-triol
(dapagliflozin; BMS-512148) is a potent sodium-glucose cotransporter type II …

[BOOK][B] Indian wars

RM Utley, WE Washburn - 2002 - books.google.com
… curbside trash cans everywhere, Washburn and I sought balance. … Heretics that we were,
Washburn and I must have struck … I am pleased with that record, and I know Wilcomb Washburn

[HTML][HTML] Liver and intestine transplantation in the United States 1998–2007

…, JK Heimbach, JC Magee, WK Washburn… - American Journal of …, 2009 - Elsevier
Liver transplantation numbers in the United States remained constant from 2004 to 2007, while
the number of waiting list candidates has trended down. In 2007, the waiting list was at its …