User profiles for Walter Brand

Walter Brand

Toxicologist (ERT), Scientific Officer at RIVM
Verified email at rivm.nl
Cited by 1700

Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients

W Brand, ME Schutte, G Williamson… - Biomedicine & …, 2006 - Elsevier
The transcellular transport of ingested food ingredients across the intestinal epithelial
barrier is an important factor determining bioavailability upon oral intake. This transcellular …

Possible effects of titanium dioxide particles on human liver, intestinal tissue, spleen and kidney after oral exposure

W Brand, RJB Peters, HM Braakhuis… - …, 2020 - Taylor & Francis
Recent studies reported adverse liver effects and intestinal tumor formation after oral exposure
to titanium dioxide (TiO 2 ). Other oral toxicological studies, however, observed no effects …

Oral intake of added titanium dioxide and its nanofraction from food products, food supplements and toothpaste by the Dutch population

…, R Peters, G van Bemmel, W Brand… - …, 2016 - Taylor & Francis
… in the brands consumed and thus be exposed to the average TiO 2 concentration of the
brands available for each food product, or at least not consume the worst case brand for each …

Overview of potential adverse health effects of oral exposure to nanocellulose

W Brand, PCE van Kesteren, E Swart, AG Oomen - Nanotoxicology, 2022 - Taylor & Francis
Nanocellulose is an emerging material for which several food-related applications are
foreseen, for example, novel food, functional food, food additive or in food contact materials. …

Metabolism and transport of the citrus flavonoid hesperetin in Caco-2 cell monolayers

W Brand, PAI Van Der Wel, MJ Rein, D Barron… - Drug Metabolism and …, 2008 - ASPET
Metabolism and transport from intestinal cells back into the lumen by ATP-binding cassette (ABC)
transporters is believed to limit the bioavailability of flavonoids. We studied metabolism …

Trigger values for investigation of hormonal activity in drinking water and its sources using CALUX bioassays

W Brand, CM de Jongh, SC van der Linden… - Environment …, 2013 - Elsevier
To screen for hormonal activity in water samples, highly sensitive in vitro CALUX bioassays
are available which allow detection of estrogenic (ERα), androgenic (AR), progestagenic (PR…

Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples

W Brand, MG Boersma, H Bik… - Drug metabolism and …, 2010 - ASPET
Phase II metabolism by UDP-glucuronosyltransferases (UGTs) and sulfotransferases (SULTs)
is the predominant metabolic pathway during the first-pass metabolism of hesperetin (4′-…

Considerations for safe innovation: the case of graphene

MVDZ Park, EAJ Bleeker, W Brand, FR Cassee… - ACS …, 2017 - ACS Publications
The terms “Safe innovation” and “Safe(r)-by-design” are currently popular in the field of
nanotechnology. These terms are used to describe approaches that advocate the consideration …

Silicon dioxide and titanium dioxide particles found in human tissues

…, S Munniks, RLAW Bleys, PC Tromp, W Brand… - …, 2020 - Taylor & Francis
Silicon dioxide (silica, SiO 2 , SAS) and titanium dioxide (TiO 2 ) are produced in high volumes
and applied in many consumer and food products. As a consequence, there is a potential …

Nanomedicinal products: a survey on specific toxicity and side effects

W Brand, CW Noorlander, C Giannakou… - International journal …, 2017 - Taylor & Francis
Due to their specific properties and pharmacokinetics, nanomedicinal products (NMPs) may
present different toxicity and side effects compared to non-nanoformulated, conventional …