Various forms of machine learning (ML) methods have historically played a valuable role in
environmental remote sensing research. With an increasing amount of “big data” from earth …

7508 Background: Chromosomal rearrangements of the ROS1 receptor tyrosine kinase
gene define a new molecular subset of NSCLC. In cell lines, ROS1 rearrangements lead to …

Background Oncogenic fusion genes consisting of EML4 and anaplastic lymphoma kinase (ALK)
are present in a subgroup of non–small-cell lung cancers, representing 2 to 7% of such …

Background Chromosomal rearrangements of the gene encoding ROS1 proto-oncogene
receptor tyrosine kinase (ROS1) define a distinct molecular subgroup of non–small-cell lung …

Discussion Crizotinib (molecular weight, 450.34) is an anaplastic lymphoma kinase (ALK)
tyrosine kinase inhibitor (TKI) 3 that leads to responses in most patients with NSCLC …

Crizotinib is a dual MET and ALK inhibitor. Currently, clinical development of crizotinib is
focused primarily on ALK rearranged non-small cell lung cancer (NSCLC). Here we report an …

In recent years, more and more higher education institutions have interests of integrating
internet-based technologies in the classroom as part of the learning environment. Compared to …

To get a better understanding of user behavior towards online learning systems, the technology
acceptance model (TAM) was extended to include an intrinsic motivational factor. An …

Purpose: To determine tolerability, pharmacokinetics, and pharmacodynamics of PD-0325901,
a highly potent, selective, oral mitogen-activated protein kinase/extracellular signal-…

Diabetic chronic wound healing still faces huge clinical challenge. The arrangement and
coordination of healing processes are disordered in diabetic wound caused by the persistent …