The anaphylatoxin C3a is a potent chemotactic peptide and inflammatory mediator released
during complement activation which binds to and activates a G-protein-coupled receptor. …

Introduction. The vitronectin receptor, also known as Rvβ3, is a member of the integrin family
of heterodimeric transmembrane glycoprotein complexes that function in cellular adhesion …

3-Pyrrolidineacetic acid (la), certain piperidinecarboxylic acids—ie, 3-piperidinecarboxylic
acid (2a), 1, 2, 5, 6-tetrahydro-3-pyridinecarboxylic acid (3a), and cis-4-hydroxy-3-…

The 6 methylchrysene isomers, synthesized in greater than 99.9% purity via unambiguous
routes, and chrysene were tested for complete carcinogenicity and tumor-initiating activity on …

Previously, we reported the direct design of highly potent nonpeptide 3-oxo-1,4-benzodiazepine
fibrinogen receptor antagonists from a constrained, RGD-containing cyclic semipeptide. …

The role of GPIIb/IIIa antagonists in the prevention of thrombosis has gained increasing
attention in recent years. 1, 2 Since chronic oral administration of GPIIb/IIIa antagonists could, in …

Methylchrysenes are present in tobacco smoke and are suspected to contribute to the
tumorigenicity of this inhalant. Chrysene and the six isomeric methylchrysenes were obtained in …

In the absence of structural data or good models for the receptor, success in mimicking natural
peptide ligands with potent non-peptides has been elusive, in part because of uncertain …

… Bondinell, Raul R. Calvo, Larry D. Davis, Karl F. … Hall, William F. Huffman, Richard M.
Keenan, Chet Kwon, Kenneth A. … CH,NH,, THF (70% from 9); e) Cbz-L-Asp-P-methyl ester …

Allometric scaling may be used in drug development to predict the pharmacokinetics of
xenobiotics in humans from animal data. Although allometry may be successful for compounds …