It is now widely accepted that the various pharmacologic and addictive consequences of
alcohol consumption are related to the tissue concentration of ethanol or its metabolic products. …

Many Orientals lack the mitochondrial aldehyde dehydrogenase (ALDH2) activity responsible
for the oxidation of acetaldehyde produced during ethanol metabolism. These individuals …

7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin (irinotecan; CPT-11) is
a prodrug activated by carboxylesterase enzymes. We characterized the hydrolysis of CPT-…

This article reports on a symposium sponsored by the American Society for Pharmacology
and Experimental Therapeutics and held at the April 2001 Experimental Biology meeting. …

Methylphenidate is an important stimulant prescribed to treat attention-deficit hyperactivity
disorder. It has two chiral centers, but most current commercial formulations consist of the …

A new, pharmacologically active metabolite of cocaine, ethylcocaine, has been reported in
individuals after concurrent use of cocaine and ethanol. Formation of ethylcocaine may …

A human liver carboxylesterase (hCE-2) that catalyzes the hydrolysis of the benzoyl group
of cocaine and the acetyl groups of 4-methylumbelliferyl acetate, heroin, and 6-…

Concomitant iv use of cocaine and heroin(“speedballing”) is prevalent among drug-abusing
populations. Heroin is rapidly metabolized by sequential deacetylation of two separate ester …

Capecitabine is an oral prodrug of 5-fluorouracil that is indicated for the treatment of breast
and colorectal cancers. A three-step in vivo-targeted activation process requiring …

Purpose: The purpose is to develop new analytical methods to study the expression profile
of CPT-11 carboxylesterases and topoisomerase I in colon tumor samples and understand …