Decreased CYP3A expression and activity in guinea pig models of diet-induced metabolic syndrome: is fatty liver infiltration involved?
D Patoine, X Levac, S Pilote, B Drolet… - Drug Metabolism and …, 2013 - ASPET
Background: In humans, CYP3A drug-metabolizing enzyme subfamily is the most important.
Numerous pathophysiological factors, such as diabetes and obesity, were shown to affect …
Numerous pathophysiological factors, such as diabetes and obesity, were shown to affect …
[HTML][HTML] Molecular imaging of the human pulmonary vascular endothelium in pulmonary hypertension: a phase II safety and proof of principle trial
…, V Finnerty, QT Nguyen, M Letourneau, X Levac… - European journal of …, 2017 - Springer
Purpose The adrenomedullin receptor is densely expressed in the pulmonary vascular
endothelium. PulmoBind, an adrenomedullin receptor ligand, was developed for molecular …
endothelium. PulmoBind, an adrenomedullin receptor ligand, was developed for molecular …
Molecular imaging of the human pulmonary vascular endothelium using an adrenomedullin receptor ligand
F Harel, X Levac, QT Nguyen… - Molecular …, 2015 - journals.sagepub.com
This phase I study (NCT01539889) evaluated the safety, efficacy, and dosing of PulmoBind
for molecular imaging of pulmonary circulation. PulmoBind is a ligand of the adrenomedullin …
for molecular imaging of pulmonary circulation. PulmoBind is a ligand of the adrenomedullin …
Metabolic syndrome potentiates the cardiac action potential-prolonging action of drugs: a possible 'anti-proarrhythmic'role for amlodipine
B Caillier, S Pilote, D Patoine, X Levac… - Pharmacological …, 2012 - Elsevier
Type II diabetes was shown to prolong the QT interval on the ECG and to promote cardiac
arrhythmias. This is not so clear for metabolic syndrome, a precursor state of type II diabetes. …
arrhythmias. This is not so clear for metabolic syndrome, a precursor state of type II diabetes. …
[HTML][HTML] Evaluation of pulmonary perfusion by SPECT imaging using an endothelial cell tracer in supine humans and dogs
X Levac, F Harel, V Finnerty, QT Nguyen… - EJNMMI research, 2016 - Springer
Background Pulmonary perfusion is not spatially homogeneously distributed, and its
variations could be of diagnostic value in lung vascular disease. PulmoBind is a ligand of the …
variations could be of diagnostic value in lung vascular disease. PulmoBind is a ligand of the …
Spatial Distribution of the Metabolically Active Pulmonary Circulation in Humans
X Levac, F Harel, V Finnerty, QT Nguyen… - Circulation, 2014 - Am Heart Assoc
Introduction: Human pulmonary perfusion is not homogeneously distributed. Analysis of
pulmonary perfusion spatial distribution (SD) variations, could be useful in the evaluation of …
pulmonary perfusion spatial distribution (SD) variations, could be useful in the evaluation of …
Evaluation of Pulmonary Perfusion Using an Endothelial Cell Tracer in Supine Humans and Dogs
1726 Objectives Pulmonary perfusion is not homogeneously distributed and its variations
could be of diagnostic value. PulmoBind is a ligand of the adrenomedullin receptor expressed …
could be of diagnostic value. PulmoBind is a ligand of the adrenomedullin receptor expressed …
MOLECULAR IMAGING OF THE HUMAN PULMONARY VASCULAR ENDOTHELIUM IN PULMONARY HYPERTENSION: THE PULMOBIND SAFETY AND PROOF …
…, QT Nguyen, V Finnerty, M Letourneau, X Levac… - Journal of the American …, 2016 - jacc.org
Background The adrenomedullin receptor is densely expressed in the pulmonary vascular
endothelium. PulmoBind, an adrenomedullin receptor ligand, was developed for molecular …
endothelium. PulmoBind, an adrenomedullin receptor ligand, was developed for molecular …
Palynological records from Bay of Islands, Newfoundland: Direct correlation of Holocene paleoceanographic and climatic changes
E Levac - Palynology, 2003 - Taylor & Francis
… Comparison of the quantitative reconstructions from La Have Basin with previous studies in
the area outlined three differences (Levac, 2001) that will be investigated in this paper. First, …
the area outlined three differences (Levac, 2001) that will be investigated in this paper. First, …
[HTML][HTML] Pulmonary Vascular Research Institute World Congress 2017 Scientific Abstracts
M Takeuchi, A Kawazoe, Y Tanaka, KE Pinkerton - ncbi.nlm.nih.gov
Cigarette smoke (CS) is a risk factor of pulmonary diseases. Honey is used as a traditional
medicine for colds and skin inflammation. It is known that lipopolysaccharides (LPS) induce …
medicine for colds and skin inflammation. It is known that lipopolysaccharides (LPS) induce …