Mesaconitine (MA) and hypaconitine (HA) are the main bioactive/toxic alkaloids of Aconitum
carmichaelii Debx, and MDR1, BCRP and MRP2 are involved in their efflux in vitro. This …

Esculetin (ET)-7-O-glucuronide (ET-G) and 4-methylesculetin (4-ME)-7-O-glucuronide (4-ME-G)
are the main glucuronide of ET and 4-ME, respectively. The disposition mediated by …

Background This study aimed to systematically profile the alterations and sex- and age-related
differences in the drug metabolizing enzymes (DMEs) in a KRAS-mutant mouse model of …

Background Bleomycin-induced fibrosis is extensively used to model aspects of the pathogenesis
of interstitial pulmonary fibrosis. This study aimed to determine the benefic effects and …

Genome-wide association studies and integrative genomics approaches have demonstrated
significant associations between chronic obstructive pulmonary disease (COPD) and single…

The hedgehog signaling pathway plays an important role in lung morphogenesis and
cellular responses to lung injury. Genome-wide association studies (GWAS) and integrative …

Objectives Genome-wide association studies (GWAS) and integrative genomics approaches
have demonstrated significant associations between chronic obstructive pulmonary …

The highly diastereoselective intramolecular [3+2] annulation via the ring-opening of a
cyclopropane diester derivative has been developed to construct a dihydroquinolinone scaffold. A …

A series of novel 2,3- or 2,5-dispirooxindole-piperazine ring systems were efficiently
constructed through the acid-promoted self-1,3-dipolar [3+3] cyclizations of azomethine ylides …

Background Mucus hypersecretion in the respiratory tract and goblet cell metaplasia in the
airway epithelium contribute to the morbidity and mortality associated with airway …