Although base editors are useful tools for precise genome editing, current base editors can
only convert either adenines or cytosines. We developed a dual adenine and cytosine base …

Trade allows regions to exchange goods and services domestically and internationally,
resulting in significant shifts in energy usage. However, what remains unclear is how these shifts …

Conventional embryonic stem cell (ESC)–based gene targeting, zinc-finger nuclease (ZFN)
and transcription activator–like effector nuclease (TALEN) technologies are powerful …

The CRISPR-Cas RNA-guided system has versatile uses in many organisms and allows
modification of multiple target sites simultaneously. Generating novel genetically modified …

Excessive RANKL signaling leads to superfluous osteoclast formation and bone resorption,
is widespread in the pathologic bone loss and destruction. Therefore, targeting RANKL or its …

In brief The current declining trend in male fertility parallels the increasing prevalence of
obesity worldwide. This paper revealed that the poor in vitro fertilization rates and decreased …

Researchers have stated that the larger the roller moment of inertia, the better the tuned
rolling cylinder damper (TRCD). However, this statement has not been confirmed. Thus, this …

This study was conducted to improve our understanding of climate changes and landscape
evolution in the transitional area between the westerly-dominated regions and monsoonal …

The biosphere experienced episodic perturbations during the Neoproterozoic–early
Cambrian, accompanied by major fluctuations of the carbon cycle. However, compared to the …

Neutrophil and neutrophil extracellular traps (NETs) were reported to be associated with
tumor development, but the exact role and concrete mechanisms are still poorly understood, …