9-[β-DL-2α,3α-Dihydroxy-4β-(hydroxymethyl)- cyclopentyl]adenine, the Carbocyclic Analog of Adenosine1,2

YF Shealy, JD Clayton - Journal of the American Chemical …, 1966 - ACS Publications
In a similar condensation of bromomesaconic ester 1 with the pyrrolidinenamine of
cyclohexanone, 4 there was produced a 76% yield of a bicyclononanone diester [II; Ci3H1805; bp …

Synthesis and evaluation of some new retinoids for cancer chemoprevention

YF Shealy - Preventive Medicine, 1989 - Elsevier
Many derivatives and analogs of the natural vitamin A compounds have been synthesized,
and some of these retinoids are very active in various bioassays that may be predictive for …

Imidazoles. I. Coupling Reactions of 5-Diazoimidazole-4-carboxamide1,2

YF Shealy, CA Krauth… - The Journal of Organic …, 1962 - ACS Publications
Ha 1-* HI extinction coefficients (e) at the absorption maxima of 2-azahypoxanthine, V-methylaniline,
and solu-tions of XIII showed that the sums of the e values of 2-azahypoxanthine …

Synthesis of carbocyclic analogs of purine ribonucleosides

YF Shealy, JD Clayton - Journal of the American Chemical …, 1969 - ACS Publications
The racemic forms of the carbocyclic (cyclopentane) analogs of adenosine, inosine, 6-mercaptopurine
ribonucleoside, and 6-(methylthio) purine ribonucleoside were synthesized from (…

Synthesis of Potential Anticancer Agents. XXIX. 5-Diazoimidazole-4-carboxamide and 5-Diazo-v-triazole-4-carboxamide1,2

YF Shealy, RF STRUCK, LEEB HOLUM… - The Journal of …, 1961 - ACS Publications
The initial product of the diazotization of 5 (or 4)-aminoimidazole-4-(or 5 [-carboxamide has
been isolated and shown to be 5-diazoimidazole-4-carboxamide. The diazo derivative, …

Syntheses and biological activity of 5-aminoimidazoles and 5-triazenoimidazoles

YF Shealy - Journal of Pharmaceutical Sciences, 1970 - Elsevier
In 1945, Stetten and Fox (1) isolated a heterocyclic amine that accumulated (1, 2) during
sulfonamide bacteriostasis of Escherichia coli and also detected this compound in sulfonamide-…

Influence of 15 retinoic acid amides on urinary bladder carcinogenesis in the mouse

RC Moon, DL McCormick, PJ Becci, YF Shealy… - …, 1982 - academic.oup.com
A series of experiments was conducted to determine the efficacy of 15 synthetic retinoic acid
amides (retinamides) as inhibitors of chemical carcinogenesis of the urinary bladder in …

Carbocyclic analogs of 5-substituted uracil nucleosides. Synthesis and antiviral activity

YF Shealy, CA O'Dell, WM Shannon… - Journal of Medicinal …, 1983 - ACS Publications
Carbocyclic analogues of S'-deoxyuridines, 3'-deoxyuridines, and uridines with substituents
at position 5 of the uracil moiety were prepared by direct halogenation (5-bromo and 5-iodo …

Nonenzymatic isomerization of 9-cis-retinoic acid catalyzed by sulfhydryl compounds

TW Shih, TH Lin, YF Shealy, DL Hill - Drug metabolism and disposition, 1997 - ASPET
Certain thiol-containing compounds catalyze, in a chemical reaction, the isomerization of 9-cis-retinoic
acid to a mixture of all-trans-retinoic acid, 9-cis-retinoic acid, 13-cis-retinoic acid, …

Synthesis of the carbocyclic analogs of uracil nucleosides

YF Shealy, CA O'Dell - Journal of Heterocyclic Chemistry, 1976 - Wiley Online Library
Abstract Treatment of the required hydroxyl derivatives of cis‐3‐aminocyclopentanemethanol
with 3‐ethoxyacryloyl isocyanate gave N‐(3‐ethoxyacryloyl)‐N′‐[hydroxy‐ or dihydroxy(…