Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products
Polyethylene glycol (PEG) is a versatile polymer that is widely used as an additive in foods
and cosmetics, and as a carrier in PEGylated therapeutics. Even though PEG is thought to be …
and cosmetics, and as a carrier in PEGylated therapeutics. Even though PEG is thought to be …
[HTML][HTML] Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor: structure-activity relationship of 2-arachidonoylglycerol, ether-linked …
…, K Waku, C Seki, N Baba, Y Ishima - Journal of Biological …, 1999 - ASBMB
An endogenous cannabimimetic molecule, 2-arachidonoylglycerol, induces a rapid,
transient increase in intracellular free Ca 2+ concentrations in NG108–15 cells through a …
transient increase in intracellular free Ca 2+ concentrations in NG108–15 cells through a …
[HTML][HTML] p-Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress by activation of NADPH oxidase
…, Q Wu, M Endo, T Noguchi, D Kadowaki, Y Ishima… - Kidney international, 2013 - Elsevier
The accumulation of p-cresyl sulfate (PCS), a uremic toxin, is associated with the mortality
rate of chronic kidney disease patients; however, the biological functions and the mechanism …
rate of chronic kidney disease patients; however, the biological functions and the mechanism …
[HTML][HTML] The new delivery strategy of albumin carrier utilizing the interaction with albumin receptors
Y Ishima, T Maruyama, M Otagiri… - Chemical and …, 2022 - jstage.jst.go.jp
Albumin, the most abundant protein in human serum, is applied to various diseases as a
drug delivery carrier because of its superior blood retention, high biocompatibility, and a wide …
drug delivery carrier because of its superior blood retention, high biocompatibility, and a wide …
[HTML][HTML] Cys34-cysteinylated human serum albumin is a sensitive plasma marker in oxidative stress-related chronic diseases
…, M Anraku, D Kadowaki, Y Ishima, Y Sasaki… - PLoS …, 2014 - journals.plos.org
The degree of oxidized cysteine (Cys) 34 in human serum albumin (HSA), as determined by
high performance liquid chromatography (HPLC), is correlated with oxidative stress related …
high performance liquid chromatography (HPLC), is correlated with oxidative stress related …
[HTML][HTML] Indoxyl sulfate potentiates skeletal muscle atrophy by inducing the oxidative stress-mediated expression of myostatin and atrogin-1
…, R Sugimoto, T Imafuku, Y Tominaga, Y Ishima… - Scientific reports, 2016 - nature.com
… Miyamoto, Y. et al. Organic anion transporters play an important role in the uptake of p-cresyl …
Jiang, Y. et al. Opposite roles of myocardin and atrogin-1 in L6 myoblast differentiation. …
Jiang, Y. et al. Opposite roles of myocardin and atrogin-1 in L6 myoblast differentiation. …
Transacylase‐Mediated and Phosphodiesterase‐Mediated Synthesis of N‐Arachidonoylethanolamine, an Endogenous Cannabinoid‐Receptor Ligand, in Rat Brain …
…, S Nakane, A Yamashita, Y Ishima… - European Journal of …, 1996 - Wiley Online Library
The levels of N‐arachidonoylethanolamine (anandamide), an endogenous cannabinoid‐receptor
ligand, and a relevant molecule, N‐arachidonoylphosphatidylethanolamine (N‐…
ligand, and a relevant molecule, N‐arachidonoylphosphatidylethanolamine (N‐…
Potential therapeutic interventions for chronic kidney disease‐associated sarcopenia via indoxyl sulfate‐induced mitochondrial dysfunction
…, S Nagao, S Miyamura, Y Ishima… - Journal of Cachexia …, 2017 - Wiley Online Library
Background Chronic kidney disease (CKD) patients experience skeletal muscle wasting and
decreased exercise endurance. Our previous study demonstrated that indoxyl sulfate (IS), a …
decreased exercise endurance. Our previous study demonstrated that indoxyl sulfate (IS), a …
[HTML][HTML] The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response
…, T Ida, T Okamoto, AK Ahtesham, Y Ishima… - Journal of biological …, 2010 - ASBMB
A nitrated guanine nucleotide, 8-nitroguanosine 3′,5′-cyclic monophosphate (8-nitro-cGMP),
is formed via nitric oxide (NO) and causes protein S-guanylation. However, intracellular 8…
is formed via nitric oxide (NO) and causes protein S-guanylation. However, intracellular 8…
Improved anticancer effects of albumin-bound paclitaxel nanoparticle via augmentation of EPR effect and albumin-protein interactions using S-nitrosated human …
R Kinoshita, Y Ishima, VTG Chuang, H Nakamura… - Biomaterials, 2017 - Elsevier
In the latest trend of anticancer chemotherapy research, there were many macromolecular
anticancer drugs developed based on enhanced permeability and retention (EPR) effect, …
anticancer drugs developed based on enhanced permeability and retention (EPR) effect, …