The accumulation of certain species of bacteria in the intestine is involved in both tissue
homeostasis and immune-mediated pathologies. The host mechanisms involved in controlling …

Human renal membrane transporters play key roles in the disposition of renally cleared
drugs and endogenous substrates, but their ontogeny is largely unknown. Using 184 human …

Uncontrolled interferon γ (IFNγ)-mediated T-cell responses to commensal microbiota are a
driver of inflammatory bowel disease (IBD). Interleukin-10 (IL-10) is crucial for controlling …

Tolerance to harmless exogenous antigens is the default immune response in the gastrointestinal
tract. Although extensive studies have demonstrated the importance of the mesenteric …

The intestinal influx oligopeptide transporter peptide transporter 1 (PEPT1) (SLC15A1) is
best known for nutrient-derived di- and tripeptide transport. Its role in drug absorption is …

Disease heterogeneity hampers achieving long-term disease remission in inflammatory
bowel disease (IBD). Monitoring ongoing tissue-localized regulatory and inflammatory T-cell …

… Raatgeep 1 , Y. Simons-Oosterhuis 1 , DH van Haaften 1 , JJ Karrich 2 , JC Escher 3 , M.
Groeneweg 4 , BE Clausen 5 , T. Cupedo 2 , JN Samsom 1 …

Rotavirus is the most important cause of viral gastroenteritis and dehydrating diarrhea in young
children. Rotavirus nonstructural protein 4 (NSP4) is an enterotoxin that was identified as …

The notion that the mucosal immune system maintains a tolerogenic response to harmless
Ags while continually being challenged with microbial products seems an enigma. The aim of …

Secretory leukocyte protease inhibitor (SLPI) is a pleiotropic protein produced by healthy
intestinal epithelial cells. SLPI regulates NF-κB activation, inhibits neutrophil proteases and has …