User profiles for Yatrik Shah
Yatrik ShahVerified email at umich.edu Cited by 13322 |
The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors
that are involved in regulating glucose and lipid homeostasis, inflammation, proliferation …
that are involved in regulating glucose and lipid homeostasis, inflammation, proliferation …
[PDF][PDF] Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency
Iron deficiency and iron overload are among the most prevalent nutritional disorders worldwide.
Duodenal cytochrome b (DcytB) and divalent metal transporter 1 (DMT1) are regulators …
Duodenal cytochrome b (DcytB) and divalent metal transporter 1 (DMT1) are regulators …
[HTML][HTML] GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis
Cancer metabolism is rewired to support cell survival in response to intrinsic and environmental
stressors. Identification of strategies to target these adaptions is an area of active …
stressors. Identification of strategies to target these adaptions is an area of active …
[PDF][PDF] Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox balance
Microbial dysbiosis is a colorectal cancer (CRC) hallmark and contributes to inflammation,
tumor growth, and therapy response. Gut microbes signal via metabolites, but how the …
tumor growth, and therapy response. Gut microbes signal via metabolites, but how the …
Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment
Oncogenic mutations in KRAS drive common metabolic programmes that facilitate tumour
survival, growth and immune evasion in colorectal carcinoma, non-small-cell lung cancer and …
survival, growth and immune evasion in colorectal carcinoma, non-small-cell lung cancer and …
Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice
I Kim, K Morimura, Y Shah, Q Yang, JM Ward… - …, 2007 - academic.oup.com
The farnesoid X receptor (FXR) controls the synthesis and transport of bile acids (BAs). Mice
lacking expression of FXR, designated Fxr -null, have elevated levels of serum and hepatic …
lacking expression of FXR, designated Fxr -null, have elevated levels of serum and hepatic …
[HTML][HTML] Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine
The gastrointestinal tract is a highly proliferative and regenerative tissue. The intestine also
harbors a large and diverse microbial population collectively called the gut microbiome (…
harbors a large and diverse microbial population collectively called the gut microbiome (…
Disruption of hypoxia-inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in high-fat diet–fed mice
…, T Chanturiya, W Jou, O Gavrilova, YM Shah… - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE Obesity, insulin resistance, and type 2 diabetes form a tightly correlated cluster
of metabolic disorders in which adipose is one of the first affected tissues. The role of …
of metabolic disorders in which adipose is one of the first affected tissues. The role of …
[HTML][HTML] HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron
Hypoxia is a hallmark of solid tumors that promotes cell growth, survival, and metastasis and
confers resistance to chemo and radiotherapies. Hypoxic responses are largely mediated …
confers resistance to chemo and radiotherapies. Hypoxic responses are largely mediated …
PPARα: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators
FJ Gonzalez, YM Shah - Toxicology, 2008 - Elsevier
Peroxisome proliferator chemicals are classic non-genotoxic carcinogens. These agents
cause liver cancers when chronically administered to rats and mice. Peroxisome proliferators …
cause liver cancers when chronically administered to rats and mice. Peroxisome proliferators …