Nicastrin functions to sterically hinder γ-secretase–substrate interactions driven by substrate transmembrane domain
DM Bolduc, DR Montagna, Y Gu… - Proceedings of the …, 2016 - National Acad Sciences
γ-Secretase is an intramembrane-cleaving protease that processes many type-I integral
membrane proteins within the lipid bilayer, an event preceded by shedding of most of the …
membrane proteins within the lipid bilayer, an event preceded by shedding of most of the …
[HTML][HTML] Modifications of H3 and H4 during chromatin replication, nucleosome assembly, and histone exchange
LJ Benson, Y Gu, T Yakovleva, K Tong… - Journal of Biological …, 2006 - ASBMB
Histone posttranslational modifications that accompany DNA replication, nucleosome
assembly, and H2A/H2B exchange were examined in human tissue culture cells. Through …
assembly, and H2A/H2B exchange were examined in human tissue culture cells. Through …
The nonclinical disposition and pharmacokinetic/pharmacodynamic properties of N-Acetylgalactosamine–conjugated small interfering RNA are highly predictable and …
…, S Chong, J Cichocki, K Fitzgerald, V Goel, Y Gu… - Drug Metabolism and …, 2022 - ASPET
Conjugation of oligonucleotide therapeutics, including small interfering RNAs (siRNAs) or
antisense oligonucleotides, to N-acetylgalactosamine (GalNAc) ligands has become the …
antisense oligonucleotides, to N-acetylgalactosamine (GalNAc) ligands has become the …
[HTML][HTML] Properties of the type B histone acetyltransferase Hat1: H4 tail interaction, site preference, and involvement in DNA repair
LJ Benson, JA Phillips, Y Gu, MR Parthun… - Journal of biological …, 2007 - ASBMB
The Hat1 histone acetyltransferase catalyzes the acetylation of H4 at lysines 5 and 12, the
same sites that are acetylated in newly synthesized histone H4. By performing histone …
same sites that are acetylated in newly synthesized histone H4. By performing histone …
Molecular identification of a bevy of serine proteinases in Manduca sexta hemolymph
Extracellular serine proteinase pathways control immune and homeostatic processes in
insects. Our current knowledge of their components is limited—prophenoloxidase-activating …
insects. Our current knowledge of their components is limited—prophenoloxidase-activating …
[HTML][HTML] Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein
T Yang, D Arslanova, Y Gu, C Augelli-Szafran, W Xia - Molecular brain, 2008 - Springer
Background Deposition of amyloid-β protein (Aβ) is a major pathological hallmark of Alzheimer's
disease (AD). Aβ is generated from γ-secretase cleavage of amyloid precursor protein (…
disease (AD). Aβ is generated from γ-secretase cleavage of amyloid precursor protein (…
The nonclinical disposition and PK/PD properties of GalNAc-conjugated siRNA are highly predictable and build confidence in translation to man
…, J Cichocki, K Fitzgerald, V Goel, Y Gu… - Drug Metabolism and …, 2021 - ASPET
Conjugation of oligonucleotide therapeutics, including small interfering ribonucleic acids (siRNAs)
or antisense oligonucleotides (ASOs) to N-acetylgalactosamine (GalNAc) ligands has …
or antisense oligonucleotides (ASOs) to N-acetylgalactosamine (GalNAc) ligands has …
In vitro drug-drug interaction evaluation of GalNAc conjugated siRNAs against CYP450 enzymes and transporters
…, S Iqbal, J Jiang, V Clausen, K Aluri, Y Gu… - Drug Metabolism and …, 2019 - ASPET
Small interfering RNAs (siRNAs) represent a new class of medicines that are smaller (∼16,000
Da) than biologic therapeutics (>150,000 Da) but much larger than small molecules (<…
Da) than biologic therapeutics (>150,000 Da) but much larger than small molecules (<…
Impact of serum proteins on the uptake and RNAi activity of GalNAc-conjugated siRNAs
S Agarwal, R Allard, J Darcy, S Chigas, Y Gu… - nucleic acid …, 2021 - liebertpub.com
Serum protein interactions are evaluated during the drug development process since they
determine the free drug concentration in blood and thereby can influence the drug's …
determine the free drug concentration in blood and thereby can influence the drug's …
Discovery of notch-sparing γ-secretase inhibitors
…, HX Wei, D Lu, J Zhang, Y Gu… - Current Alzheimer …, 2010 - ingentaconnect.com
Overwhelming evidence supports a central role for the amyloid β-peptide (Aβ) in the
pathogenesis of Alzheimer's disease (AD), and the proteases that produce Aβ from its precursor …
pathogenesis of Alzheimer's disease (AD), and the proteases that produce Aβ from its precursor …