[HTML][HTML] Decreased extra-renal urate excretion is a common cause of hyperuricemia

…, Y Ikebuchi, K Ito, M Nakamura, Y Shinohara… - Nature …, 2012 - nature.com
ABCG2, also known as BCRP, is a high-capacity urate exporter, the dysfunction of which
raises gout/hyperuricemia risk. Generally, hyperuricemia has been classified into urate '…

Pharmacokinetics, placental transfer, and neonatal effects of vecuronium and pancuronium administered during cesarean section

…, SM Shnider, CL Baysinger, Y Shinohara… - Survey of …, 1984 - journals.lww.com
Pharmacokinetics, Placental Transfer, and Neonatal Effects o... : Survey of Anesthesiology
Pharmacokinetics, Placental Transfer, and Neonatal Effects of Vecuronium and Pancuronium …

Pharmacokinetic properties of testosterone propionate in norman men

M FUJIOKA, Y SHINOHARA, S BABA… - The Journal of …, 1986 - academic.oup.com
The pharmacokinetic characteristics of testosterone propionate were studied in normal men
after a single im dose of 25 mg testosterone propionate-19,i9,19-d 3 ; Plasma levels of …

Pharmacokinetics and toxicokinetics of d-serine in rats

H Hasegawa, N Masuda, H Natori, Y Shinohara… - … of Pharmaceutical and …, 2019 - Elsevier
In the mammalian brain, d-serine acts as a co-agonist at the glycine-binding site on the N-methyl-d-aspartate
receptor. Because plasma d-serine levels are significantly lower in patients …

[HTML][HTML] Direct detection and evaluation of conversion of D-methionine into L-methionine in rats by stable isotope methodology

H Hasegawa, Y Shinohara, K Akahane… - The Journal of nutrition, 2005 - Elsevier
The stereoselective kinetics of methionine enantiomers in rats was investigated to evaluate
the fraction that converted from D-methionine to the L-enantiomer using a stable isotope …

Simultaneous determination of methionine and total homocysteine in human plasma by gas chromatography–mass spectrometry

Y Shinohara, H Hasegawa, K Tagoku… - … of Chromatography B …, 2001 - Elsevier
A gas chromatographic–mass spectrometric method for the simultaneous determination of
methionine and total homocysteine in human plasma is described. dl-[ 2 H 4 ]Methionine and …

Kinetics of intramolecular acyl migration of 1β-O-acyl glucuronides of (R)-and (S)-2-phenylpropionic acids

H Hasegawa, K Akira, Y Shinohara… - Biological and …, 2001 - jstage.jst.go.jp
MATERIALS AND METHODS The HPLC system consisted of a Waters (Milford, MA, USA)
M600E multisolvent system, a Waters U6K injector, and a Waters lambda Max 481 UV …

Studies on the stereoselective internal acyl migration of ketoprofen glucuronides using 13C labeling and nuclear magnetic resonance spectroscopy

…, T Taira, H Hasegawa, C Sakuma, Y Shinohara - Drug metabolism and …, 1998 - ASPET
Internal acyl migration reactions of drug 1β-O-acyl glucuronides are of interest because of
their possible role in covalent binding to serum proteins and consequent allergic reactions as …

Absorption, metabolism, and excretion of oral testosterone in humans by mass fragmentography

Y SHINOHARA, S BABA… - The Journal of Clinical …, 1980 - academic.oup.com
A mass fragmentographic method employing stable isotopically labeled testosterone was
employed to follow the time course of urinary excretion of the two main testosterone …

Distinct effects of folate and choline deficiency on plasma kinetics of methionine and homocysteine in rats

Y Shinohara, H Hasegawa, K Ogawa, K Tagoku… - Metabolism, 2006 - Elsevier
Both folate and betaine, a choline metabolite, play essential roles in the remethylation of
homocysteine to methionine. We have studied the effects of folate and choline deficiency on the …