Formulation design and photochemical studies on nanocrystal solid dispersion of curcumin with improved oral bioavailability

S Onoue, H Takahashi, Y Kawabata, Y Seto… - Journal of …, 2010 - Elsevier
Considerable interest has been focused on curcumin due to its use to treat a wide variety of
disorders, however, the therapeutic potential of curcumin could often be limited by its poor …

Novel solid self-emulsifying drug delivery system of coenzyme Q10 with improved photochemical and pharmacokinetic behaviors

…, A Uchida, K Kuriyama, T Nakamura, Y Seto… - European journal of …, 2012 - Elsevier
The present study was undertaken to develop a solid self-emulsifying drug delivery system
of coenzyme Q 10 (CoQ 10 /s-SEDDS) with high photostability and oral bioavailability. The …

Development of high-energy amorphous solid dispersion of nanosized nobiletin, a citrus polymethoxylated flavone, with improved oral bioavailability

S Onoue, A Uchida, H Takahashi, Y Seto… - Journal of …, 2011 - Elsevier
Nobiletin (NOB), a citrus polymethoxylated flavone, attracts attention because of a wide
range of pharmacological activities such as anti-inflammation, anticancer, and most notably …

[HTML][HTML] Photosafety assessments on pirfenidone: photochemical, photobiological, and pharmacokinetic characterization

Y Seto, R Inoue, M Kato, S Yamada, S Onoue - Journal of Photochemistry …, 2013 - Elsevier
Pirfenidone (PFD), an idiopathic pulmonary fibrosis drug, has phototoxic risk in clinical use,
although its detailed mechanisms for the phototoxicity have never been fully elucidated. In …

Chemical photoallergy: photobiochemical mechanisms, classification, and risk assessments

S Onoue, Y Seto, H Sato, H Nishida, M Hirota… - Journal of …, 2017 - Elsevier
Chemical photosensitivity can be elicited by exposure of the skin to various pharmaceutical
substances, foods, cosmetics and other environmental chemicals, followed by exposure to …

Drug-induced phototoxicity; an early in vitro identification of phototoxic potential of new drug entities in drug discovery and development

S Onoue, Y Seto, G Gandy, S Yamada - Current Drug Safety, 2009 - ingentaconnect.com
Drug-induced photoirritation can be defined as an inflammatory reaction of the skin after
topical or systemic administration of pharmaceutical substances. In many cases of drug-induced …

Establishment and intra‐/inter‐laboratory validation of a standard protocol of reactive oxygen species assay for chemical photosafety evaluation

…, Y Matsumoto, S Kawakami, Y Seto… - Journal of Applied …, 2013 - Wiley Online Library
A reactive oxygen species (ROS) assay was previously developed for photosafety evaluation
of pharmaceuticals, and the present multi‐center study aimed to establish and validate a …

Reactive oxygen species assay-based risk assessment of drug-induced phototoxicity: classification criteria and application to drug candidates

…, M Fujikawa, H Yamada, Y Tsuda, Y Seto… - … of pharmaceutical and …, 2008 - Elsevier
We have previously demonstrated that the phototoxic potential of chemicals could be partly
predicted by the determination of reactive oxygen species (ROS) from photo-irradiated …

Enhanced pharmacokinetic behavior and hepatoprotective function of ginger extract-loaded supersaturable self-emulsifying drug delivery systems

…, H Suzuki, K Shiokawa, H Kikuchi, Y Seto… - Journal of functional …, 2018 - Elsevier
The aim of present study was to enhance the nutraceutical properties of ginger extract (GE)
by employing supersaturable self-emulsifying drug delivery systems (S-SEDDS). SEDDS of …

Anti-inflammatory effects of the selective phosphodiesterase 3 inhibitor, cilostazol, and antioxidants, enzymatically-modified isoquercitrin and α-lipoic acid, reduce …

Y Kangawa, T Yoshida, H Abe, Y Seto… - Experimental and …, 2017 - Elsevier
Developing effective treatments and preventing inflammatory bowel disease (IBD) are urgent
challenges in improving patients’ health. It has been suggested that platelet activation and …