Near completely humanized liver in mice shows human-type metabolic responses to drugs
…, R Utoh, C Yamasaki, A Tachibana, Y Soeno… - The American journal of …, 2004 - Elsevier
Human hepatocytes were transplanted into urokinase-type plasminogen activator-transgenic
SCID mice (uPA/SCID mice), which are immunodeficient and undergo liver failure. The …
SCID mice (uPA/SCID mice), which are immunodeficient and undergo liver failure. The …
Expression of human cytochromes P450 in chimeric mice with humanized liver
…, M Nakajima, C Tateno, M Kataoka, Y Soeno… - Drug metabolism and …, 2004 - ASPET
Recently, a chimeric mouse line in which the liver could be replaced by more than 80% with
human hepatocytes was established in Japan. Because the chimeric mouse produces …
human hepatocytes was established in Japan. Because the chimeric mouse produces …
In vivo drug metabolism model for human cytochrome P450 enzyme using chimeric mice with humanized liver
M Katoh, T Sawada, Y Soeno, M Nakajima… - Journal of …, 2007 - Elsevier
We previously clarified that major human drug metabolizing enzymes were expressed in a
chimeric urokinase-type plasminogen activator (uPA) +/+ /severe combined immunodeficient (…
chimeric urokinase-type plasminogen activator (uPA) +/+ /severe combined immunodeficient (…
Humanization of excretory pathway in chimeric mice with humanized liver
…, M Katoh, T Sawada, M Nakajima, Y Soeno… - Toxicological …, 2007 - academic.oup.com
The liver of a chimeric urokinase-type plasminogen activator (uPA) +/+ /severe combined
immunodeficient (SCID) mouse line recently established in Japan could be replaced by more …
immunodeficient (SCID) mouse line recently established in Japan could be replaced by more …
Generation of functional β-actinin (CapZ) in an E. coli expression system
Y Soeno, H Abe, S Kimura, K Maruyama… - Journal of Muscle …, 1998 - Springer
β-actinin (CapZ) is a heterodimeric actin-binding protein which caps the barbed end of actin
filaments and nucleates actin-polymerization in a Ca2+-independent manner. In myofibrils it …
filaments and nucleates actin-polymerization in a Ca2+-independent manner. In myofibrils it …
In vivo induction of human cytochrome P450 enzymes expressed in chimeric mice with humanized liver
…, T Matsui, M Nakajima, C Tateno, Y Soeno… - Drug metabolism and …, 2005 - ASPET
The induction and inhibition of human cytochrome P450 (P450) enzymes are clinically
responsible for drug interactions. Although the induction of P450s is investigated using human …
responsible for drug interactions. Although the induction of P450s is investigated using human …
Generation of hybrid hepatocytes by cell fusion from monkey embryoid body cells in the injured mouse liver
…, S Arii, K Takase, M Kataoka, Y Soeno… - Histochemistry and cell …, 2006 - Springer
Monkey embryonic stem (ES) cells have characteristics that are similar to human ES cells,
and might be useful as a substitute model for preclinical research. When embryoid bodies (…
and might be useful as a substitute model for preclinical research. When embryoid bodies (…
Evaluation of human CYP1A2 and CYP3A4 mRNA expression in hepatocytes from chimeric mice with humanized liver
…, M Kataoka, E Takahashi, Y Soeno… - Drug metabolism and …, 2006 - jstage.jst.go.jp
We investigated and compared the expression of human CYPs mRNA in primary cultures of
cryopreserved human hepatocytes and in chimeric mice constructed by transplanting …
cryopreserved human hepatocytes and in chimeric mice constructed by transplanting …
Organization of connectin/titin filaments in sarcomeres of differentiating chicken skeletal muscle cells
Y Soeno, H Yajima, Y Kawamura, S Kimura… - Muscle Physiology and …, 1999 - Springer
Very long, elastic connectin/titin molecules position the myosin filaments at the center of a
sarcomere by linking them to the Z line. The behavior of the connectin filaments during …
sarcomere by linking them to the Z line. The behavior of the connectin filaments during …
Effects of Exogenous 0-Actinin (CapZ) on Actin Filamentous Structures in Cultured Muscle Cells
Y Soeno, K Hayakawa, T Obinata - Zoological science, 1998 - BioOne
β-Actinin (CapZ) is a heterodimeric actin-binding protein which is localized in the Z-bands of
myofibril. It caps the barbed end of actin filaments and nucleates actin-polymerization in a …
myofibril. It caps the barbed end of actin filaments and nucleates actin-polymerization in a …