In the last 50 years, lipid peroxidation has been the subject of extensive studies from the
viewpoints of mechanisms, dynamics, product analysis, involvement in diseases, inhibition, and …

Deletion and point (L166P) mutations of DJ‐1 have recently been shown to be responsible
for the onset of familial Parkinson's disease (PD, PARK7). The aim of this study was to …

The liver may regulate glucose homeostasis by modulating the sensitivity/resistance of
peripheral tissues to insulin, by way of the production of secretory proteins, termed hepatokines. …

Introduction: Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are
rare but life-threatening severe cutaneous adverse reactions. Recently, strong associations of …

Glutathione peroxidase catalyzes the reduction of hydrogen peroxide and organic
hydroperoxide by glutathione and functions in the protection of cells against oxidative damage. …

Many investigations about the cellular response by metal oxide nanoparticles in vitro have
been reported. However, the influence of the adsorption ability of metal oxide nanoparticles …

Selenium is an essential trace element and it is well known that selenium is necessary for
cell culture. However, the mechanism underlying the role of selenium in cellular proliferation …

Selenoprotein P is an extracellular protein containing presumably 10 selenocysteines that
are encoded by the UGA stop codon in the open reading frame of the mRNA. The function of …

Objectives SN-38, an active metabolite of irinotecan, is detoxified by glucuronidation with
UGT1A isoforms, 1A1, 1A7, 1A9, and 1A10. The pharmacogenetic information on UGT1A …

Drug lag, recently discussed extensively in Japan, can be divided into two phases: clinical
development time and application review time. The former factor is still an important problem …