Purpose. The ability of monoclonal antibodies against the human insulin receptor to undergo
transcytosis through the blood-brain barrier (BBB) was examined in the present studies. …

Taraxacum officinale has been widely used as a folkloric medicine for the treatment of diverse
diseases. The dried plant was extracted with 70% ethanol to generate its ethanol extract (…

The blood–brain barrier (BBB) transport of brain-derived neurotrophic factor (BDNF) in
anesthetized rats was examined in the present studies using vector-mediated peptide drug …

Immunoliposomes directed by monoclonal antibodies are promising vehicles for tumor targeted
drug delivery. Development of a long-circulating formulation of pH-sensitive liposomes (…

An in vivo model of chronic hypoglycemia was used to investigate changes in blood-brain
barrier(BBB) glucose transport activity and changes in the expression of GLUT1 mRNA and …

The mechanism that removes homovanillic acid (HVA), an end metabolite of dopamine, from
the brain is still poorly understood. The purpose of this study is to identify and characterize …

Polyamide ("peptide") nucleic acids (PNAs) are molecules with antigene and antisense
effects that may prove to be effective neuropharmaceuticals if these molecules are enabled to …

The hypothesis that P‐glycoprotein plays a functional role at the brain capillary endothelium,
which makes up the blood‐brain barrier in vivo, is based largely on immunocytochemical …

The blood-brain barrier (BBB) permeability to morphine and morphine-6-glucuronide (M6G)
is measured under identical conditions using an intravenous injection method in the rat and …

Taurine is the abundant sulfur‐containing β‐amino acid in brain where it exerts a
neuroprotective effect. Although it is known that the blood–brain barrier (BBB) mediates taurine …