Characterization of divergent metabolic pathways in elucidating an unexpected, slow-forming, and long half-life major metabolite of Iclepertin

…, P Liu, HH Maw, KG Raymond, YS Scaringella… - Pharmaceutical …, 2023 - Springer
Purpose After single oral dosing of the glycine reuptake transporter (GlyT1) inhibitor, iclepertin
(BI 425809), a single major circulating metabolite, M530a, was identified. However, upon …

Human liver microsomes immobilized on magnetizable beads: a novel approach to study in vitro drug metabolism

AM Horspool, T Wang, YS Scaringella, ME Taub… - Drug Metabolism and …, 2020 - ASPET
Human liver microsomes (HLM) are a commonly used tool to study drug metabolism in vitro.
Typical experiments conducted using suspensions of HLM can be challenging to separate …

Evaluation of erythromycin as a tool to assess CYP3A contribution of low clearance compounds in a long-term hepatocyte culture

TS Chan, YS Scaringella, K Raymond… - Drug Metabolism and …, 2020 - ASPET
Long-term hepatocyte culture systems such as HepatoPac are well suited to evaluate the
metabolic turnover of low clearance (CL) drugs because of their sustained metabolic capacity …

[CITATION][C] P6-Comparison of techniques to assess non-specific microsomal binding

T Chan, A Whitcher-Johnstone, YS Scaringella… - Drug Metabolism and …, 2020 - cir.nii.ac.jp
Young-Sun Scaringella