Aryl hydrocarbon receptor counteracts pharmacological efficacy of doxorubicin via enhanced AKR1C3 expression in triple negative breast cancer cells
N Yamashita, Y Kanno, N Saito, K Terai… - Biochemical and …, 2019 - Elsevier
Triple-negative breast cancer (TNBC) is associated with poor prognosis, because of no
effective targeted therapy. In the present study, we demonstrated the crucial role of the aryl …
effective targeted therapy. In the present study, we demonstrated the crucial role of the aryl …
Picrasidine G decreases viability of MDA-MB 468 EGFR-overexpressing triple-negative breast cancer cells through inhibition of EGFR/STAT3 signaling pathway
…, S Zhao, W Li, K Koike, K Nemoto, Y Kanno - Bioorganic & medicinal …, 2017 - Elsevier
Targeted therapy is unavailable for treating patients with triple-negative breast cancer (TNBC),
which accounts for approximately 15% of all breast cancers. Overexpression of epidermal …
which accounts for approximately 15% of all breast cancers. Overexpression of epidermal …
Activation of the aryl hydrocarbon receptor represses mammosphere formation in MCF-7 cells
S Zhao, Y Kanno, M Nakayama, M Makimura, S Ohara… - Cancer letters, 2012 - Elsevier
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor. Recent
studies have reported the anti-tumor effects of the AhR in breast cancer. In this study, we …
studies have reported the anti-tumor effects of the AhR in breast cancer. In this study, we …
Activation of the aryl hydrocarbon receptor by 3-methylcholanthrene, but not by indirubin, suppresses mammosphere formation via downregulation of CDC20 …
…, A Kase, M Ozawa, C Taga, N Sanada, Y Kanno… - Biochemical and …, 2021 - Elsevier
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates
various toxicological and biological functions. We reported previously that 3-…
various toxicological and biological functions. We reported previously that 3-…
Camalexin, an indole phytoalexin, inhibits cell proliferation, migration, and mammosphere formation in breast cancer cells via the aryl hydrocarbon receptor
N Yamashita, C Taga, M Ozawa, Y Kanno… - Journal of natural …, 2022 - Springer
Breast cancer is the most commonly diagnosed cancer among women worldwide. Despite a
variety of drugs available for the treatment of patients with breast cancer, drug resistance …
variety of drugs available for the treatment of patients with breast cancer, drug resistance …
HER2 overexpression-mediated inflammatory signaling enhances mammosphere formation through up-regulation of aryl hydrocarbon receptor transcription
S Zhao, S Ohara, Y Kanno, Y Midorikawa… - Cancer letters, 2013 - Elsevier
The interaction between HER2 and aryl hydrocarbon receptor (AhR) signaling cascades
during mammosphere formation of MCF-7 cells was studied. A newly established clonal MCF-7 …
during mammosphere formation of MCF-7 cells was studied. A newly established clonal MCF-7 …
Heregulin-induced cell migration is promoted by aryl hydrocarbon receptor in HER2-overexpressing breast cancer cells
…, N Hiruta, Y Park, H Bujo, K Nemoto, Y Kanno - Experimental cell …, 2018 - Elsevier
HER2 overexpression accounts for approximately 15–20% of all breast cancers. We have
shown that HER2 overexpression leads to elevated expression of the aryl hydrocarbon …
shown that HER2 overexpression leads to elevated expression of the aryl hydrocarbon …
Selective androgen receptor modulator, yk11, up-regulates osteoblastic proliferation and differentiation in mc3t3-e1 cells
…, K Kato, Y Inouye, K Nemoto, Y Kanno - Biological and …, 2018 - jstage.jst.go.jp
Androgens are key regulators that play a critical role in the male reproductive system and
have anabolic effects on bone mineral density and skeletal muscle mass. We have previously …
have anabolic effects on bone mineral density and skeletal muscle mass. We have previously …
A consecutive three alanine residue insertion mutant of human CAR: a novel CAR ligand screening system in HepG2 cells
Y Kanno, Y Inouye - The Journal of toxicological sciences, 2010 - jstage.jst.go.jp
The expression of the CAR gene is lost in most cultured cell lines, and exogenously
expressed CAR accumulates spontaneously in the nuclear compartment, where CAR is …
expressed CAR accumulates spontaneously in the nuclear compartment, where CAR is …
A dihydrochalcone and several homoisoflavonoids from Polygonatum odoratum are activators of adenosine monophosphate-activated protein kinase
H Guo, H Zhao, Y Kanno, W Li, Y Mu, X Kuang… - Bioorganic & medicinal …, 2013 - Elsevier
Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a major cellular energy
sensor and master regulator of metabolic homeostasis; thus, AMPK plays a central role in …
sensor and master regulator of metabolic homeostasis; thus, AMPK plays a central role in …