The kidney proximal tubule is the primary site in the nephron for excretion of waste products
through a combination of active uptake and secretory processes and is also a primary target …

The discovery of small-molecule inhibitors requires suitable binding pockets on protein
surfaces. Proteins that lack this feature are considered undruggable and require innovative …

Cytochrome P450 3A4 (CYP3A4) is a multifunctional enzyme involved in both xenobiotic
and endobiotic metabolism. This review focuses on two aspects: regulation of CYP3A4 …

Vitamin D 3 is critical for the regulation of calcium and phosphate homeostasis. In some
individuals, mineral homeostasis can be disrupted by long-term therapy with certain antiepileptic …

Rationale: Vitamin D deficiency is common in patients with asthma and chronic obstructive
pulmonary disease (COPD). Low 25-hydroxyvitamin D (25[OH]D) levels may represent a …

Hyperactivation of mTOR kinase by mutations in the PI3K/mTOR pathway or by crosstalk with
other mutant cancer drivers, such as RAS, is a feature of many tumors. Multiple allosteric …

The clinical benefits of pan-mTOR active-site inhibitors are limited by toxicity and relief of
feedback inhibition of receptor expression. To address these limitations, we designed a series …

Simultaneous and accurate measurement of circulating vitamin D metabolites is critical to
studies of the metabolic regulation of vitamin D and its impact on health and disease. To that …

Long‐term therapy with certain drugs, especially cytochrome P450 (P450; CYP)‐inducing
agents, confers an increased risk of osteomalacia that is attributed to vitamin D deficiency. …

Background Decreased glomerular filtration rate (GFR) leads to reduced production of 1,25-dihydroxyvitamin
D 3 from 25-hydroxyvitamin D 3 (25[OH]D 3 ). Effects of low GFR on vitamin …