Lipophilic properties of the compound allow to predict its fate in living organisms and to
propose the models of chemicals transport and accumulation in the ecosystem. Lipophilicity is …

The final therapeutic effect of a drug candidate, which is directed to a specific molecular target
strongly depends on its absorption, distribution, metabolism and excretion (ADME). The …

Lipophilicity of the compounds is useful to (i) explain their distribution in biological systems,
which is different in plant and in animal organisms, (ii) predict the possible pathways of …

The use of nanoparticles for the controlled drug delivery to cells has emerged as a good
alternative to traditional systemic delivery. Quantum dots (QDs) offer potentially invaluable …

A promising strategy for overcoming the problem of limited efficacy in antitumor drug
delivery and in drug release is the use of a nanoparticle-conjugated drug. Doxorubicin (Dox) …

New promising unsymmetrical bisacridine derivatives (UAs), have been developed. Three
groups including 36 compounds were synthesized by the condensation of 4-nitro or 4-…

The acridinone derivates 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone (C-1305)
and 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) are promising …

To limit cytotoxicity of anticancer drugs against healthy cells, an appropriate carrier should
be synthesized to deliver the drug to the tumor tissue only. A good solution is to anchor a …

The imidazoacridinone derivative, C-1311, is an antitumor agent that has been under phase
I of clinical trial. The work presented here aims to elucidate the molecular mechanism of the …

A method is presented for the electroanalytical characterization of interactions of dsDNA
with a drug, under conditions that both agents are dissolved in the phosphate buffer solution …