The oxidationof benzo [o] pyrene (B [o] P) was examined using reconstituted systems prepared
with recombinant human cytochromeP450 (P450) enzymes 1A1, 1A2, 2C8, 2C10, 2E1, …

Cytochrome P450 (P450) 2D6 is the classic human liver debrisoquine 4-hydroxylase, the first
human P450 for which genetic polymorphism was clearly demonstrated. We prepared 11 …

Phenethyl isothiocyanate (PEITC), a constituent of cruciferous vegetables, has been shown
to inhibit chemical carcinogenesis, possibly due to its ability to block the activation or to …

Background: Dried blood spot (DBS) sampling could potentially become the preferred blood
collection technique in toxicological and clinical studies. Autoradiography was performed to …

Aryl acetylenes have been investigated as inhibitors of cytochrome P450 (P450)-dependent
alkoxyresorufin dealkylation activities in liver microsomes prepared from rats exposed to β-…

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent tobacco-specific nitrosamine
in animals and has been suggested to play a role in human tobacco-related cancers. Our …

The specificities of orphenadrine and methimazole on eight human liver P450 enzyme
activities were evaluated by studying the extent of inhibition at different concentrations in two …

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a potent tobacco-specific carcinogen
in animals, has been linked to tobacco-related cancers in humans. The cytochrome(s) P-…

Bufuralol 1 ‘-hydroxylation is a prototypical reaction catalyzed by cytochrome P450 (P450)
2D6, an enzyme known to show debrisoquine/sparteine-type genetic polymorphism in …

Many arylalkyl isothiocyanates are potent inhibitors of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
(NNK)-induced lung tumorigenesis in rats and mice. In the mouse, 4-phenylbutyl …