An important component of precision medicine—the use of whole-genome sequencing (WGS)
to guide lifelong healthcare—is electronic decision support to inform drug choice and …

Cytochrome P450 (CYP) 2D6, a major contributor to the metabolism and bioactivation of many
clinically used drugs, is encoded by a complex, highly polymorphic gene locus. To aid in …

Although CYP2B6 catalyzes the biotransformation of many drugs used clinically for children
and adults, information regarding the effects of development on CYP2B6 expression and …

Maternal cigarette smoking during pregnancy is associated with increased risk of perinatal
morbidity and mortality. However, the mechanisms underlying adverse birth outcomes …

CYP2D6 contributes to the metabolism of many clinically used drugs and is increasingly
tested to individualize drug therapy. The CYP2D6 gene is challenging to genotype due to the …

Despite the established interindividual variability and ontogeny of the CYP3A enzymes, the
most abundant phase I drug-metabolizing enzymes in human liver and intestine, the …

TaqMan™ genotyping assays are widely used to genotype CYP2D6, which encodes a major
drug metabolizing enzyme. Assay design for CYP2D6 can be challenging owing to the …

Background: CYP2D6, a major drug-metabolizing enzyme, is encoded by a highly polymorphic
and complex gene locus. We have identified a patient who failed to produce a CYP2D6 …

… Greyson P Twist, Andrea Gaedigk, Neil A Miller, Emily G Farrow, Laurel K Willig, Darrell L
Dinwiddie, Josh E Petrikin, Sarah E Soden, Suzanne Herd, Margaret Gibson, Julie A Cakici …

Background Differences in mRNA expression for inflammatory markers have been observed
between subjects with asthma vs. controls and in relation to corticosteroid response. …